CRM Co-Director, Farsh Guilak PhD, was elected to the National Academy of Engineering for “contributions to regenerative medicine and mechanobiology and their application to the development of clinical therapies.” Election to the National Academy of Engineering is among the highest professional distinctions accorded to an engineer. Congratulations, Farsh, on this richly-deserved honor.
Category: People News & Publications
FGFR Syndromes virtual symposium planned
A virtual symposium on FGFR syndromes is planned for March 17-18, 2022. Dave Ornitz, who is a member of the Born a Hero Medical Advisory Board, will be presenting.
Kroll lab research featured in NPR podcast and AP article (Links to an external site)
Research from the Kroll lab (Developmental Biology) was recently featured in an article from the Associated Press and The Takeaway podcast from NPR. This research, done in collaboration with Joe Dougherty’s lab, describes creating mouse models and iPSC lines carrying mutations for a patient’s mutations in MYT1L, to better understand autism. NPR podcast – https://www.npr.org/podcasts/381444253/pri-the-takeaway?utm_source=NPR
Kristen Kroll promoted to Full Professor
Congrats to Kristen Kroll, PhD (Developmental Biology) who was promoted to full professor.
Millman and Morris awarded tenure
Congratulations to Jeff Millman, PhD (Endocrinology) and Sam Morris, PhD (Genetics and Developmental Biology) who were both promoted to associate professor with tenure!
Transcript assembly improves expression quantification of transposable elements in single-cell RNA-seq data (Links to an external site)
Shao, W., *Wang, T. Genome Research, 2021, 31(1), pp. 88–100
Adipose tissue is a critical regulator of osteoarthritis (Links to an external site)
Kelsey H. Collins, Kristin L. Lenz, Eleanor N. Pollitt, Daniel Ferguson, Irina Hutson, Luke E. Springer, Arin K. Oestreich, Ruhang Tang, Yun-Rak Choi, *Gretchen A. Meyer, *Steven L. Teitelbaum, *Christine T. N. Pham, Charles A. Harris, and *Farshid Guilak. PNAS USA, 18 (1) e2021096118, 2021.
Computational Stem Cell Biology: Open Questions and Guiding Principles (Links to an external site)
Cahan, P., Cacchiarelli, D., Dunn, S.-J., (…), *Morris, SA, Rackham, OJL, del Sol, A., Wells, C.A. Cell Stem Cell, 28(1), pp. 20-32, 2021.
Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee (Links to an external site)
Bailey, K.N., Furman, B.D., Zeitlin, J., (…), *Guilak, F., Olson, S.A. Osteoarthritis and CartilageVolume 28, Issue 5, May 2020, Pages 626-638.
Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter (Links to an external site)
Dicks, A., Wu, C.-L., Steward, N., (…), Gersbach, C.A., *Guilak, F. Stem Cell Research and Therapy, Volume 11, Issue 1, 18 February 2020, Article number 66.
Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis (Links to an external site)
Hagan, A.S., *Zhang, B., *Ornitz, D.M. Development,Volume 147: Article number dev181032, 2020.
The role of macrophages in osteoarthritis and cartilage repair (Review) (Links to an external site)
Wu, C.-L., Harasymowicz, N.S., Klimak, M.A., Collins, K.H., *Guilak, F. Osteoarthritis and Cartilage, Volume 28: 544-554, 2020.
High oxygen preservation hydrogels to augment cell survival under hypoxic condition (Links to an external site)
Niu, H., Li, C., Guan, Y., (…), Ma, L., *Guan, J. Acta BiomaterialiaVolume 105, 15 March 2020, Pages 56-67.
The age-dependent effect of high-dose X-ray radiation on NFκB signaling, structure, and mechanical behavior of the intervertebral disc (Links to an external site)
Liu, J.W., Piersma, S., *Tang, S.Y. Connective Tissue ResearchVolume 61, Issue 3-4, 3 July 2020, Pages 399-408.
Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development (Links to an external site)
Kelly, N.H., Huynh, N.P.T., *Guilak, F. Matrix Biology, Volume 89, Pages 1-10 2020.
Rapid determination of internal strains in soft tissues using an experimentally calibrated finite element model derived from magnetic resonance imaging (Links to an external site)
Yoon, D.H.E., Weber, C.I., Easson, G.W.D., Broz, K.S., *Tang, S.Y. Quantitative Imaging in Medicine and Surgery, Volume 10, Issue 1, 2020, Pages 57-65.
Proximal tubule translational profiling during kidney fibrosis reveals proinflammatory and long noncoding RNA expression patterns with sexual dimorphism (Links to an external site)
Wu, H., Lai, C.-F., Chang-Panesso, M., *Humphreys, B.D. Journal of the American Society of Nephrology, Volume 31: 23-38, 2020.
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes (Links to an external site)
Meyer, M., Ben-Yehuda Greenwald, M., Rauschendorfer, T., (…), *Ornitz, D.M., Werner, S. Journal of Cellular and Molecular Medicine,Volume 24: 1774-1785, 2019.
Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation (Links to an external site)
Shea, C.A., Rolfe, R.A., *McNeill, H., Murphy, P. Dev Dyn, Volume 249: 523-542, 2020.
Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients (Links to an external site)
Zhang, C.R.C., Nix, D., Gregory, M., (…), Spencer, D.H., *Challen, G.A. Experimental HematologyVolume 80: 36-41.e3, 2019.
SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water (Links to an external site)
Li, H., Russo, A., *DiAntonio, A. J Cell Biology, Volume 218: 4017-4029, 2019.
Prioritizing functional goals as we rebuild the kidney (Links to an external site)
*Humphreys, B.D., Knepper, M.A. JASN, Volume 30: 2287-2288, 2019.
Myocardial glucose and fatty acid metabolism is altered and associated with lower cardiac function in young adults with Barth syndrome (Links to an external site)
*Cade, W.T., Laforest, R., Bohnert, K.L., (…), Gropler, R.J., Peterson, L.R. Journal of Nuclear Cardiology, 2019.
Aaron DiAntonio receives Javits Neuroscience Investigator Award from NINDS
Aaron DiAntonio (Department of Developmental Biology) received a Javits Neuroscience Investigator Award (R37) from the NINDS. Recipients must be nominated by NINDS staff and demonstrate significant, paradigm-shifting contributions to the NINDS mission. The award converts a standard R01 into a 7-year grant. Congratulations, Aaron!
DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration (Links to an external site)
Summers, D.W., Frey, E., Walker, L.J., *Milbrandt, J., *DiAntonio, A. Molecular Neurobiology, Volume 57, Issue 2, 1 February 2020, Pages 1146-1158, 2019.
Fat/Dachsous family cadherins in cell and tissue organisation (Links to an external site)
Fulford, A.D., *McNeill, H. Current Opinion in Cell Biology, 62, pp. 96-103, 2020.
Cis-regulatory basis of sister cell type divergence in the vertebrate retina (Links to an external site)
Murphy, D.P., Hughes, A.E., Lawrence, K.A., Myers, C.A., *Corbo, J.C. eLife, Volume 8, October 2019, Article number e48216, 2019.
β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea (Links to an external site)
Jansson, L., Ebeid, M., Shen, J.W., (…), Huh, S.-H., Cheng, A.G. PNAS, 116(42), pp. 21054-21060, 2019.
DNA Damage Prediction Tool in Dilated Cardiomyopathy: Don’t Go Breaking My Heart (Links to an external site)
Jimenez, J., *Rentschler, S.L. JACC: Basic to Translational Science, 4(6), pp. 681-683, 2019.
Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction (Links to an external site)
Fan, Z., Xu, Z., Niu, H., (…), Ma, J., *Guan, J. Journal of Controlled Release, 311-312, pp. 233-244, 2019.
Platelet-Rich Plasma Released From Polyethylene Glycol Hydrogels Exerts Beneficial Effects on Human Chondrocytes (Links to an external site)
Jain, E., Chinzei, N., Blanco, A., (…), *Rai, M.F., Zustiak, S.P. Journal of orthopaedic research 37(11), pp. 2401-2410, 2019.
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice (Links to an external site)
Yoshida, M., Satoh, A., Lin, J.B., (…), *Apte, R.S., *Imai, S.-I. Cell Metabolism, 30(2), pp. 329-342.e5, 2019.
The single-cell transcriptomic landscape of early human diabetic nephropathy (Links to an external site)
Wilson, P.C., Wu, H., Kirita, Y., (…), Waikar, S.S., *Humphreys, B.D. PNAS, 116(39), pp. 19619-19625, 2019.
Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program (Links to an external site)
Geisler, S., Doan, R.A., Cheng, G.C., (…), *Milbrandt, J., *DiAntonio, A. JCI Insight, 4(17), art. no. e129920, 2019.
Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury (Links to an external site)
Brophy, R.H., Cai, L., Duan, X., (…), *Guilak, F., *Rai, M.F. Osteoarthritis and Cartilage, 27:1778-1789, 2019.
FGF2-induced STAT3 activation regulates pathologic neovascularization (Links to an external site)
Dong, Z., Santeford, A., Ban, N., (…), *Ornitz, D.M., *Apte, R.S. Experimental Eye Research, 187, art. no. 107775, 2019.
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death (Links to an external site)
Wan, L., Essuman, K., Anderson, R.G., (…), *DiAntonio, A., *Milbrandt, J., Dangl, J.L., Nishimura, M.T. Science, 365(6455), pp. 799-803.
Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome (Links to an external site)
Russo, A., DiAntonio, A. Cell Rep Volume 28, Issue 10, 3 September 2019, Pages 2581-2593.e5, 2019.
Macrophage Plasticity and Function in the Eye and Heart (Links to an external site)
Wang, Z., Koenig, A.L., *Lavine, K.J., *Apte, R.S., Trends Immunol, Volume 40, Issue 9, September 2019, Pages 825-841, 2019.
Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner (Links to an external site)
Yang, L.M., Cheah, K.S.E., Huh, S.-H., *Ornitz, D.M., PLoS Genetics, Volume 15, Issue 7, July 2019, Article number e1008254, 2019.
Transcriptional and Epigenetic Regulation of Cardiac Electrophysiology (Links to an external site)
Jimenez, J., Rentschler, S.L., Pediatric Cardiology, 2019
Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18) (Links to an external site)
Hagan, A.S., Boylan, M., Smith, C., (…), Lewandoski, M., Ornitz, D.M. Dev Dyn, 2019.
Guilak lab postdoc receives K99/R00 from NIAMS
Chia-Lung Wu, a postdoc in Farsh Guilak’s lab, was awarded a highly-competitive K99/R00 from NIAMS to understand the epigenetic regulation of chondrogenesis during development and directed differentiation.
Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia (Links to an external site)
Carlin, D., Halevi, A.E., Ewan, E.E., Moore, A.M., Cavalli, V. eNeuro, 6, 2019.
Thyroid hormone regulates distinct paths to maturation in pigment cell lineages (Links to an external site)
Saunders, L.M., Mishra, A.K., Aman, A.J., (…), Corbo, J.C.,* Trapnell, C., Parichy, D.M. eLife, 8:e45181, 2019.
miR-892b Inhibits Hypertrophy by Targeting KLF10 in the Chondrogenesis of Mesenchymal Stem Cells (Links to an external site)
Lee, J.M., Ko, J.-Y., Kim, H.Y., (…), *Guilak, F., Im, G.-I. Molecular Therapy – Nucleic Acids, 17:310-322, 2019.
Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts (Links to an external site)
Hegab, A.E., Ozaki, M., Kameyama, N., (…), *Ornitz, D.M., Betsuyaku, T. J Pathol, 2019.
Insights into traumatic brain injury from MRI of harmonic brain motion (Links to an external site)
Okamoto, R.J., Romano, A.J., Johnson, C.L., *Bayly, P.V. J Exp Neurosci, 13, 2019.
Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes (Links to an external site)
McKenzie, J., Smith, C., Karuppaiah, K., (…), *Silva, M.J., *Ornitz, D.M. J Bone Min Res, 2019.
Paper from Humphreys & Morris labs featured in ‘The Best of Cell Stem Cell 2018’ (Links to an external site)
The recent collaborative paper from the Humphreys and Morris labs, titled ‘Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics’ was featured in ‘The Best of Cell Stem Cell 2018.’ The most-highly accessed papers of 2018 were included in this special issue. Congrats to everyone on the team!