DiAntonio Lab publication (Links to an external site)

Russo, A., Goel, P., Brace, E.J., (…), Dickman, D., DiAntonio, A. The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat. EMBO Rep, art. e46975, 2019.

New review article from Apte Lab

Apte, R.S., Chen, D.S., Ferrara, N. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell, 2019.

Guilak Lab paper (Links to an external site)

Harasymowicz, N.S., Dicks, A., Wu, C.-L., Guilak, F. Physiologic and pathologic effects of dietary free fatty acids on cells of the joint. Annals New York Acad Sci, 2019.

Regis O’Keefe wins Shands Award from ORS

Regis O’Keefe MD, PhD  (Professor and Head of Orthopedic Surgery) was honored with the Alfred R. Shands, Jr, MD Award at the 2019 meeting of the Orthopedic Research Society. This award is presented to a United States or Canadian citizen who has made significant contributions to orthopaedics. This award recognizes the devotion of a significant […]

New Cavalli Lab publication (Links to an external site)

Oh, Y.M., Mahar, M., Ewan, E.E., (…), Zhao, G., Cavalli, V. Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. PNAS, 115:E12417-26, 2018.

CRM celebrates faculty accomplishments

On January 9th, the Center of Regenerative Medicine celebrated the successes of some of our faculty members. Promotion to associate professor with tenure (Grant Challen, Medicine; Spencer Lake, Mechanical Engineering; Andrew Yoo, Developmental Biology), promotion to full professor (Indira Mysorekar, Ob/Gyn), fellowship in the AAAS (Lila Solnica-Krezel, Developmental Biology and Deborah Rubin, Medicine), and installation […]

Gene therapy study has implications for nerve degeneration (Links to an external site)

Aaron DiAntonio and Jeff Milbrant recently demonstrated the power of blocking the SARM1 pathway for preventing nerve degeneration. Building on previous work, they used adeno-associated virus to deliver a dominant-negative form of the SARM1 protein to mice. When axons in these mice were injured, they were resistant to degeneration. These studies have implications for many […]

Guilak Lab publication (Links to an external site)

Venkatesan, J.K., Moutos, F.T., Rey-Rico, A., (…), Guilak, F., Cucchiarini, M. Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(∈-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer. Human Gene Ther, 29:1277-86, 2018.

New paper from the DiPersio Lab (Links to an external site)

Alahmari, B., Cooper, M., Ziga, E., (…), DiPersio, J.F., Choi, J. Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation. PLoS One, 13, p.e0207609, 2018.

New Imai Lab paper

Johnson, S., Wozniak, D.F., Imai, S. CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves.npj Aging and Mechanisms of Disease, 4(1), art. no. 10, 2018.

New paper from the Guilak Lab (Links to an external site)

Adkar, S.S., Wu, C.-L., Willard, V.P., (…), Gersbach, C.A., Guilak, F. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing. Stem Cells, 37:65-76, 2019.

New paper from the Challen Lab (Links to an external site)

Celik, H., Koh, W.K., Kramer, A.C., (…), Oh, S.T., Challen, G.A. JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells. Cancer Cell 34:741-756.e8, 2018.

Ornitz Lab wins FASEB BioArt Competition (Again!) (Links to an external site)

Lu Yang (PhD student), Sung-Ho Huh (former postdoc), and David Ornitz (PI) are among the winners of the 2018 FASEB BioArt competition for their stunning image of the olfactory epithelium within the mouse nasal cavity. The Ornitz Lab also won in 2017 for their X-ray microscopy study showing blood flow in the lungs. Congrats!

New Guilak Lab publication (Links to an external site)

Adkar SS, Wu C-L, Willard VP, Dicks A, Ettyreddy A, Steward N, Bhutani N, Gersbach CA, Guilak F. Step‐Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR‐Cas9 Genome Editing. Stem Cells, online, 2018.