Karpova, D., Rettig, M.P., Ritchey, J., (…), Link, D.C., *DiPersio, J.F., The Journal of clinical investigation, 130, 2019.
Category: People News & Publications
Injectable Oxygen Sensitive Chitosan Complex with High Oxygen Sensitivity and Stability to Oxidoreductants (Links to an external site)
Li, C., Huang, Z., Gao, N., (…), Niu, H., *Guan, J., ACS Biomaterials Science and Engineering, 5(5), pp. 2173-2179, 2019.
Recent Insights into Kidney Injury and Repair from Transcriptomic Analyses (Links to an external site)
Kirita, Y., Chang-Panesso, M., *Humphreys, B.D., Nephron, 2019.
Acoustic trap-and-release for rapid assessment of cell motility (Links to an external site)
Kim, M., Huff, E., Bottier, M., (…), *Bayly, P.V., Meacham, J.M., Soft Matter, 15(21), pp. 4266-4275, 2019.
Challenges to Routine Genetic Testing for Inherited Rod Dystrophies (Links to an external site)
Li, A.S., MacKay, D., Chen, H., Rajagopal, R., *Apte, R.S., Ophthalmology, in press, 2019.
Journal of Orthopaedic Research: Special Issue on Stem Cells (Links to an external site)
*Guilak, F., *Sandell, L., Huard, J., 2019.
Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy (Links to an external site)
*DiAntonio, A, Pain, 160, pp. S17-S22, 2019.
Blunted fat oxidation upon submaximal exercise is partially compensated by enhanced glucose metabolism in children, adolescents, and young adults with Barth syndrome (Links to an external site)
*Cade, W.T., Bohnert, K.L., Peterson, L.R., (…), Byrne, B.J., Reeds, D.N., Journal of Inherited Metabolic Disease, 42(3), pp. 480-493, 2019.
Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis (Links to an external site)
Mallaney, C., Ostrander, E.L., Celik, H., (…), *Zhang, B., *Challen, G.A, Leukemia, 2019.
NANOROBOTS: Intracellular manipulation and measurement with multipole magnetic tweezers (Links to an external site)
Wang, X., Ho, C., Tsatskis, Y., (…), *McNeill, H., Sun, Y., Science Robotics, 4(28), art. no. eaav6180, 2019.
Immune escape of AML cells after transplantation (Links to an external site)
Marín-Hernández, D., Iñiguez, L.P., Nixon, D.F., (…), *DiPersio, J.F., Ley, T.J., New England Journal of Medicine, 380(13), pp. 1289-1290, 2019.
HDAC5 promotes optic nerve regeneration by activating the mTOR pathway (Links to an external site)
Pita-Thomas, W., Mahar, M., Joshi, A., Gan, D., *Cavalli, V., Experimental Neurology, 317, pp. 271-283, 2019.
Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway (Links to an external site)
Arbouzova, N.I., Fulford, A.D., Zhang, H., *McNeill, H., Developmental Biology, Volume 450, Issue 1, 1 June 2019, Pages 23-33, 2019.
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling (Links to an external site)
Zhang, H., Bagherie-Lachidan, M., Badouel, C., (…), *Jain, S., *McNeill, H., Developmental Cell, 48(6), pp. 780-792.e4, 2019.
Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly (Links to an external site)
Lahrouchi, N., George, A., Ratbi, I., (…), Brooks, B.P., Sefiani, A., Nature Communications, 10(1), art. no. 1180, 2019.
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes (Links to an external site)
Lin, J.B., Lin, J.B., Chen, H.C., Chen, T., *Apte, R.S., Scientific Reports, 9(1), art. no. 3799, 2019.
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury (Links to an external site)
Shin, J.E., Ha, H., Kim, Y.K., Cho, Y., DiAntonio, A., Neurobiology of Disease, 127, pp. 178-192, 2019.
Behavioral Compensations and Neuronal Remodeling in a Rodent Model of Chronic Intervertebral Disc Degeneration (Links to an external site)
Leimer, E.M., Gayoso, M.G., Jing, L., (…), Gupta, M.C., Setton, L.A., Scientific Reports, 9(1), art. no. 3759, 2019.
Rich Li wins biomedical engineering 1st prize at Graduate Student Senate Research Symposium (Links to an external site)
Rich Li, a BME student in Stacey Rentschler’s lab, won 1st prize among biomedical engineering students presenting at the WUSTL Graduate Student Senate Research Symposium. Congrats Rich! Other CRM student participants included Kristina Maxwell (Millman Lab), Punn Augsornworawat (Millman Lab), and Bisi Fashemi (Mysorekar Lab).
Visualizing the Heterogeneity of Retinal Microglia (Links to an external site)
Lin, J.B., *Apte, R.S. Immunity, 50:544-46, 2019.
Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis (Links to an external site)
Kabir, A.U., Lee, T.-J., Pan, H., (…), Miller, M.J., Choi, K. JCI Insight, 3, 2018.
Injectable, thermosensitive, fast gelation, bioeliminable, and oxygen sensitive hydrogels (Links to an external site)
Li, C., Huang, Z., Gao, N., Zheng, J., *Guan, J. Materials Science and Engineering C, 99: 1191-1198, 2019.
Research from the Guan lab featured in The Record (Links to an external site)
Research from Dr. Jianjun Guan (MEMS) was featured in the Feb 25 issue of The Record. Dr. Guan and his team are developing novel biomaterials to directly deliver therapies to the infarcted heart.
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice (Links to an external site)
*Geisler, S., Huang, S.X., Strickland, A., (…), *DiAntonio, A., *Milbrandt, J. J Exp Med, 216(2), pp. 294-303, 2019.
TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension (Links to an external site)
Gilchrist, C.L., Leddy, H.A., Kaye, L., (…), Hoffman, B.D., *Guilak, F. PNAS U S A, 116(6), pp. 1992-1997, 2019.
AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome (Links to an external site)
Suzuki-Hatano, S., Saha, M., Rizzo, S.A., (…), *Cade, W.T., Pacak, C.A. Human Gene Therapy, 30(2), pp. 139-154, 2019.
AAV9-TAZ Gene Replacement Ameliorates Cardiac TMT Proteomic Profiles in a Mouse Model of Barth Syndrome (Links to an external site)
Suzuki-Hatano, S., Saha, M., Soustek, M.S., (…), Cade, W.T., Pacak, C.A. Molecular Therapy – Methods and Clinical Development, 13, pp. 167-179, 2019.
DiAntonio Lab publication (Links to an external site)
Russo, A., Goel, P., Brace, E.J., (…), Dickman, D., DiAntonio, A. The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat. EMBO Rep, art. e46975, 2019.
DiPersio leads 1st US clinical trial with ApoGraf to prevent GvHD (Links to an external site)
Dr. John DiPersio (Department of Medicine, Chief, Division of Oncology) will lead the first US Phase I/II clinical trial for ApoGraf, a stem cell selection technology developed by Cellect Biotechnology. ApoGraf is designed to prevent acute Graft vs. Host Disease following bone marrow transplant.
New review article from Apte Lab
Apte, R.S., Chen, D.S., Ferrara, N. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell, 2019.
Guilak Lab paper (Links to an external site)
Harasymowicz, N.S., Dicks, A., Wu, C.-L., Guilak, F. Physiologic and pathologic effects of dietary free fatty acids on cells of the joint. Annals New York Acad Sci, 2019.
Regis O’Keefe wins Shands Award from ORS
Regis O’Keefe MD, PhD (Professor and Head of Orthopedic Surgery) was honored with the Alfred R. Shands, Jr, MD Award at the 2019 meeting of the Orthopedic Research Society. This award is presented to a United States or Canadian citizen who has made significant contributions to orthopaedics. This award recognizes the devotion of a significant […]
Collaborative paper from Rai, Sandell, Tang, and Silva Labs (Links to an external site)
Rai, M.F., Sandell, L.J., Barrack, T.N., (…), Silva, M.J., Barrack, R.L. A Microarray Study of Articular Cartilage in Relation to Obesity and Severity of Knee Osteoarthritis. Cartilage, 2018.
Review article from the Humphreys Lab (Links to an external site)
Wilson, P.C., Humphreys, B.D. Single-cell genomics and gene editing: implications for nephrology. Nat Rev Nephrol, 2018.
Review article from the Guilak Lab (Links to an external site)
Qu, F., Guilak, F., Mauck, R.L. Cell migration: implications for repair and regeneration in joint disease. Nat Rev Rheumatol, 2019.
Review article from the Ornitz Lab (Links to an external site)
Ornitz, D.M., Marie, P.J. Fibroblast growth factors in skeletal development. Curr Opin Dev Biol, 2019.
New Cavalli Lab publication (Links to an external site)
Oh, Y.M., Mahar, M., Ewan, E.E., (…), Zhao, G., Cavalli, V. Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. PNAS, 115:E12417-26, 2018.
David Ornitz named a Fellow of American Association of Anatomists (Links to an external site)
David Ornitz, Alumni Endowed Professor of Developmental Biology, was named a Fellow of the American Association of Anatomists, an honor designed to recognize distinguished members who have demonstrated excellence in science and in their overall contributions to the anatomical sciences.
CRM celebrates faculty accomplishments
On January 9th, the Center of Regenerative Medicine celebrated the successes of some of our faculty members. Promotion to associate professor with tenure (Grant Challen, Medicine; Spencer Lake, Mechanical Engineering; Andrew Yoo, Developmental Biology), promotion to full professor (Indira Mysorekar, Ob/Gyn), fellowship in the AAAS (Lila Solnica-Krezel, Developmental Biology and Deborah Rubin, Medicine), and installation […]
Gene therapy study has implications for nerve degeneration (Links to an external site)
Aaron DiAntonio and Jeff Milbrant recently demonstrated the power of blocking the SARM1 pathway for preventing nerve degeneration. Building on previous work, they used adeno-associated virus to deliver a dominant-negative form of the SARM1 protein to mice. When axons in these mice were injured, they were resistant to degeneration. These studies have implications for many […]
Shin Imai’s lab discovers NMN transporter (Links to an external site)
In a paper recently published in the inaugural issue of Nature Metabolism, Shin Imai’s lab reported on the identity of the NMN transporter, a key molecule with implications for aging.
New paper from the Humphreys and Morris Labs (Links to an external site)
Wu, H., Uchimura, K., Donnelly, E.L., (…), Morris, S.A., Humphreys, B.D. Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics. Cell Stem Cell, 23:869-81, 2018.
Guilak Lab publication (Links to an external site)
Venkatesan, J.K., Moutos, F.T., Rey-Rico, A., (…), Guilak, F., Cucchiarini, M. Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(∈-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer. Human Gene Ther, 29:1277-86, 2018.
New paper from Rai and Sandell Labs (Links to an external site)
Rai, M.F., Brophy, R.H., Sandell, L.J. Osteoarthritis following meniscus and ligament injury: insights from translational studies and animal models. Curr Opin Rheumatol, 31:70-79, 2019.
New paper from the DiPersio Lab (Links to an external site)
Alahmari, B., Cooper, M., Ziga, E., (…), DiPersio, J.F., Choi, J. Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation. PLoS One, 13, p.e0207609, 2018.
New Imai Lab paper
Johnson, S., Wozniak, D.F., Imai, S. CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves.npj Aging and Mechanisms of Disease, 4(1), art. no. 10, 2018.
New paper from the Guilak Lab (Links to an external site)
Adkar, S.S., Wu, C.-L., Willard, V.P., (…), Gersbach, C.A., Guilak, F. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing. Stem Cells, 37:65-76, 2019.
New paper from the Challen Lab (Links to an external site)
Celik, H., Koh, W.K., Kramer, A.C., (…), Oh, S.T., Challen, G.A. JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells. Cancer Cell 34:741-756.e8, 2018.
Ornitz Lab wins FASEB BioArt Competition (Again!) (Links to an external site)
Lu Yang (PhD student), Sung-Ho Huh (former postdoc), and David Ornitz (PI) are among the winners of the 2018 FASEB BioArt competition for their stunning image of the olfactory epithelium within the mouse nasal cavity. The Ornitz Lab also won in 2017 for their X-ray microscopy study showing blood flow in the lungs. Congrats!
New Guilak Lab publication (Links to an external site)
Adkar SS, Wu C-L, Willard VP, Dicks A, Ettyreddy A, Steward N, Bhutani N, Gersbach CA, Guilak F. Step‐Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR‐Cas9 Genome Editing. Stem Cells, online, 2018.