Alumni Endowed Professor of Developmental Biology and of Medicine, Division of Cardiology
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The Nerbonne lab studies the molecular mechanisms controlling the properties, the cell surface expression, and the function of voltage (K+) gated channels in the cardiovascular and nervous systems.
Assistant Professor, Department of Biology
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If humans lose their reproductive cells (i.e eggs and sperm) they become infertile, in contrast, some animals regenerate their reproductive cells and reproductive organs. The Ozpolat lab's goal is to uncover the mechanisms of reproductive cell and tissue regeneration by identifying the cell types and genes involved in this process, which will inform regenerative medicine approaches.
Gene K. Beare Distinguished Professor of Biomedical Engineering
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The Pappu Lab studies the molecular basis of neurodegeneration, phase transitions that lead to protein and RNA condensates driven by multivalent molecules, the biophysics of intrinsically disordered proteins, and design of responsive, protein-based biomaterials. This includes multiscale computer simulations, adaptations and developments of polymer physics theories, in vitro experiments, and collaborations that enable molecular and cellular level investigations.
Associate Professor, Orthopedic Surgery
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The Patra lab is interested in identifying and analyzing regulatory pathways that impact skeletal development. In particular, the lab is exploring roles for the proprotein convertase Site-1 protease (S1P) in cartilage, bone, and spine development.
Assistant Professor, Department of Orthopedic Surgery
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Dr. Rai is interested in understanding the early molecular mechanisms that orchestrate changes in knee joint after injury and lead to the development of post-traumatic osteoarthritis.
Professor, Division of Nephrology, Department of Medicine
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Dr. Rauchman’s research focuses on understanding the molecular and genetic basis of mammalian kidney development, how disruption of specific pathways leads to abnormal development of this organ, the consequences of injury to adult kidney and the relationship between genetic mutations in humans and the development of future cardiovascular and renal disorders in humans.
Assistant Professor; Division of Endocrinology, Metabolism, and Lipid Research; Department of Medicine
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The major focus of the Remedi laboratory is to study in vivo physiology in various mouse models of diabetes to unravel the underlying mechanisms of pancreatic β-cell failure and their consequences in both pancreatic and extra-pancreatic tissues.
Executive Director, Center of Regenerative Medicine; Assistant Professor of Medicine; Assistant Professor of Cell Biology and Physiology
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The Scheller laboratory synthesizes concepts from cell biology, physiology, and bioengineering to study the relationships between the nervous system and the skeleton. They have a directed interest in understanding how neural signals contribute to skeletal homeostasis, and how perturbations to this system contribute to bone loss, impaired healing, and altered regeneration. They also seek to understand how skeletal cells and proteins coordinate and regulate nerve regeneration in and on the bone.
Assistant Professor, Otolaryngology
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The Sheets lab uses zebrafish as a model system to understand how senory hair cells of the auditory system develop, degenerate, and regenerate. A main focus of the lab is to identify biological pathways that promote nerve regeneration and hair-cell reinnervation with the goal of providing information toward clinical regenerative therapies.
Instructor, Orthopedic Surgery
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Dr. Shen's group studies biological and mechanical factors that regulate tendon development, injury, and repair, as a basis to develop new therapeutic approaches to improve tendon healing.
Assistant Professor, Orthopedic Surgery
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The Shen laboratory recently works on epigenetics of degenerative and regenerative processes in the muscuoskeletal system, e.g. osteoarthritis and bony fracture. They employ unbiased approaches to study the genomic and epigenomic alterations in skeletal diseases.
Julia and Walter R. Peterson Orthopaedic Research Professor, Orthopedic Surgery
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The Silva lab studies the mechanical and molecular factors that regulate loading-induced bone formation and bone injury response and repair.
Associate Professor, Department of Surgery
The Snyder-Warwick Lab investigates cellular signaling at the neuromuscular junction and the roles of terminal Schwann cells during development, disease, neural regeneration and muscular reinnervation, and aging. The goals of our work are to identify the mechanisms of terminal Schwann cell function that may be manipulated into novel translational applications for clinical management of patients with nerve pathology.
Co-Director, Center of Regenerative Medicine; Alan A. and Edith L. Wolff Distinguished Professor and Head of Developmental Biology
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The Solnica-Krezel lab studies the cellular and molecular genetic mechanisms underlying vertebrate gastrulation in zebrafish and human embryonic stem cells.
Instructor, Department of Pediatrics
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Dr. Stone studies the role of Fibroblast Growth Factors in Severe Insulin Resistance Syndromes. His research uses both murine and stem cell based models to better understand these rare and debilitating conditions, with the ultimate goal of providing new therapies for these patients.
Assistant Professor, Cell Biology & Physiology
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The Stratman Lab is interesting in the mechanosensitive mechanisms that regulate tissue development and patterning, particularly of the cardiovascular system. Utilizing zebrafish as a model, their goals focus on understanding developmental pathways that are reactivated during disease.
Associate Professor, Orthopedic Surgery
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The Tang lab integrates engineering and biology approaches to investigate mechanisms of degeneration relating to bone fragility and intervertebral disc degeneration, with an emphasis in the role of advanced glycation endproducts (AGEs) and RAGE signaling on the cells and tissues of the skeletal system.
Assistant Professor, Developmental Biology; co-Director Human Cells, Tissues, and Organoids Core
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The Theunissen lab investigates the molecular mechanisms regulating distinct pluripotent stem cell states and their applications in regenerative medicine.
Professor, Division of Bone and Mineral Diseases, Department of Medicine
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The Veis Laboratory studies NF-kB signaling pathways in bone cells, particularly in the context of pathological bone loss, such as in osteoporosis, inflammatory arthritis, and cancer metastasis to bone. A major focus is on the role of the alternative/non-canonical NF-kB pathway in osteoclasts, where it controls both differentiation and activity.
Assistant Professor, Department of Medicine, Division of Allergy and Immunology
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Dr. Leyao Wang's research focuses on lung microbiota and their role in lung inflammation and asthma. One of the lab's current direction is to establish a lung organoid system so that they can use this model to investigate the interactions between microbes and epithelium.
Sanford C. and Karen P. Loewentheil Distinguished Professor, Genetics
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The Wang lab focuses on understanding genetic and epigenetic factors that determine cell fate, including cell fate decision in normal development and differentiation, abnormal cell fate choice in cancer, and how specific cell types evolve.
Assistant Professor, Ophthalmology and Visual Sciences
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The Williams lab is interested in selective neuronal vulnerability in degeneration and trauma. We use a combination of in vivo microscopy, transcriptomics, and viral mediated gene overexpression/knockout to manipulate neurons in the retina with the long term goal of increasing neuronal survival and axon regeneration in degenerative mouse models.
Assistant Professor, Physical Therapy and Orthopaedic Surgery
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The Zellers Lab (Tendon Rehabilitation Lab) is committed to improving care for people with tendon injury and dysfunction. Our research is aimed at advancing our understanding of person-specific factors that affect a tendon’s ability to respond to treatment. This includes local factors, like tendon structure, and systemic factors, like the presence of diabetes.