After a two-year hiatus, faculty from the CRM gathered at the Missouri Botanical Gardens to celebrate their many accomplishments, including promotions, individual awards, and the retirement of HCTO Core Director, Mariana Beltcheva.
Author: abowman
CRM begins search for new Executive Director
The Center of Regenerative Medicine is seeking qualified candidates to become the Executive Director of the Center of Regenerative Medicine. The successful candidate will work closely with the Center Directors and other faculty members of the Center on the Center’s vision and to administer, coordinate, and facilitate collaborative research in regenerative medicine. Duties include managing […]
CRM reaches 100 members!
The CRM recently welcomed 4 new CRM members: Tony Tsai (Developmental Biology), Yao Chen (Neuroscience), Tristan Li (Neuroscience), and Michelle Oyen (BME), bringing our member count to 100!
CRM Co-Director Elected to National Academy of Engineering
CRM Co-Director, Farsh Guilak PhD, was elected to the National Academy of Engineering for “contributions to regenerative medicine and mechanobiology and their application to the development of clinical therapies.” Election to the National Academy of Engineering is among the highest professional distinctions accorded to an engineer. Congratulations, Farsh, on this richly-deserved honor.
FGFR Syndromes virtual symposium planned
A virtual symposium on FGFR syndromes is planned for March 17-18, 2022. Dave Ornitz, who is a member of the Born a Hero Medical Advisory Board, will be presenting.
Kroll lab research featured in NPR podcast and AP article (Links to an external site)
Research from the Kroll lab (Developmental Biology) was recently featured in an article from the Associated Press and The Takeaway podcast from NPR. This research, done in collaboration with Joe Dougherty’s lab, describes creating mouse models and iPSC lines carrying mutations for a patient’s mutations in MYT1L, to better understand autism. NPR podcast – https://www.npr.org/podcasts/381444253/pri-the-takeaway?utm_source=NPR
Greenberg awarded tenure
Congratulations to Michael Greenberg, PhD (Biochemistry and Molecular Biophysics), who was promoted to associate professor with the granting to tenure!
Joint Developmental Biology/DRSCB Graduate Program Retreat
Contributed by Dana Shaw, PhD and Jiameng Sun After almost two years since the last in-person inaugural Joint Retreat and one year since we joined for the second annual Joint Retreat over Zoom, the third annual Joint Retreat featuring the department of Developmental Biology (DB); the Developmental, Regenerative, and Stem Cell Biology (DRSCB) graduate program, […]
Call for Seed Grants
The CRM is pleased to call for applications for our 1-year, $50,000 (direct costs) seed grants, focused on diverse areas of regenerative medicine. All areas are eligible, with special consideration given to: Human pluripotent stem cells (hPSCs) Newly initiated interdisciplinary collaborations among CRM members The intersection of precision medicine and regenerative medicine Translational and/or entrepreneurial […]
HCTO is Hiring! (Links to an external site)
The Human Cells, Tissues, and Organoids Core has an immediate opening for a Research Tech II. This is a great opportunity for someone with a BA/BS to work on multiple exciting stem cell projects. https://bit.ly/2UKg7rA or go to WUSTL jobs and search for JR60220.
Kristen Kroll promoted to Full Professor
Congrats to Kristen Kroll, PhD (Developmental Biology) who was promoted to full professor.
Millman and Morris awarded tenure
Congratulations to Jeff Millman, PhD (Endocrinology) and Sam Morris, PhD (Genetics and Developmental Biology) who were both promoted to associate professor with tenure!
Postbaccalaureate program launched (Links to an external site)
Together with the Department of Developmental Biology, we are thrilled to announce the official launch of our postbaccalaureate program. This is a 2-year, fully-funded program designed to provide recent graduates with immersive research opportunities and additional professional development. Applications are open until March 31, 2021. See https://sites.wustl.edu/devbioregenmedpostbacc/ for full details.
Transcript assembly improves expression quantification of transposable elements in single-cell RNA-seq data (Links to an external site)
Shao, W., *Wang, T. Genome Research, 2021, 31(1), pp. 88–100
Adipose tissue is a critical regulator of osteoarthritis (Links to an external site)
Kelsey H. Collins, Kristin L. Lenz, Eleanor N. Pollitt, Daniel Ferguson, Irina Hutson, Luke E. Springer, Arin K. Oestreich, Ruhang Tang, Yun-Rak Choi, *Gretchen A. Meyer, *Steven L. Teitelbaum, *Christine T. N. Pham, Charles A. Harris, and *Farshid Guilak. PNAS USA, 18 (1) e2021096118, 2021.
Computational Stem Cell Biology: Open Questions and Guiding Principles (Links to an external site)
Cahan, P., Cacchiarelli, D., Dunn, S.-J., (…), *Morris, SA, Rackham, OJL, del Sol, A., Wells, C.A. Cell Stem Cell, 28(1), pp. 20-32, 2021.
Early Career Kidney Disease & Regenerative Medicine Seed Grants Awarded
Drs. Jeannine Basta (Nephrology) and Brian Wong (Surgery) were awarded our Early Career Kidney Disease & Regenerative Medicine Seed Grants, which were offered in collaboration with the Division of Nephrology. Dr. Basta will work on the role of SWI/SNF component Brg1 in chromatin regulation of proximal tubule cells after AKI and Dr. Wong will focus […]
New Director of HCTO Named
We are pleased to announce the hiring of Kuo-Chan Weng, PhD, as the new Director of our Human Cells, Tissues, and Organoids Core. KC brings 10 years of experience working with human pluripotent stem cells. We are grateful to our former Director, Mariana Beltcheva, PhD, for many years of dedicated service.
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration (Links to an external site)
Yo Sasaki, Hiroki Kakita, Shunsuke Kubota, Abdoulaye Sene, Tae Jun Lee, Norimitsu Ban, Zhenyu Dong, Joseph B Lin, Sanford L Boye, *Aaron DiAntonio, Shannon E Boye, *Rajendra S Apte, *Jeffrey Milbrandt. eLife 2020;9:e62027.
Congrats to DB/DRSCB Retreat presentation award winners
Congratulations the the postdocs and students who won awards for their talks at the recent joint DB/DRSCB retreat. Prizes were sponsored by the CRM. Rita Levi-Montalcini Awards for Best Student Presentation – Margaret Hayne (DiAntonio Lab); Runner up: Bisiayo Fashemi (Mysorekar Lab); Victor Hamburger Awards for Best Postdoc Presentation – Andrea Scharf (Kornfeld Lab); Runner […]
Early Career Kidney Disease & Regenerative Medicine Seed Grants RFA
The CRM is partnering with the Division of Nephrology to offer 2 1-year, $20,000 seed grants that focus on the intersection of regenerative medicine and kidney disease. These awards are open to WUSTL early career investigators (postdocs, instructors, assistant professors who have not received significant independent funding). Full details can be found in the attached […]
Developmental Biology & DRSCB Program meet for virtual joint retreat
The Department of Developmental Biology and the Development, Regeneration, and Stem Cell Biology PhD Program met for their second annual virtual retreat on October 8-9. The virtual retreat featured talks from trainees and faculty. Thanks to DRSCB students Laura Fischer and Maple Adkins-Threats for organizing, with help from Aaron Johnson and Helen McNeill.
Samantha Morris named NYSCF Robertson Investigator (Links to an external site)
Samantha Morris PhD, Assistant Professor of Developmental Biology and of Genetics, was named a Robertson Investigator of the New York Stem Cell Foundation. The NYSCF Investigator Program fosters and encourages promising early career scientists whose cutting-edge research holds the potential to accelerate treatments and cures. Dr. Morris will use the $1.5 million award to continue […]
Opening for Human Cells, Tissues, and Organoids Core Director
The CRM is looking for a Senior Scientist who will serve as the Director of our Human Cells, Tissues, and Organoids (hCTO) Core.
Derivation of trophoblast stem cells from naïve human pluripotent stem cells (Links to an external site)
Dong, C., *Beltcheva, M., *Gontarz, P., (…), *Solnica-Krezel, L., *Theunissen, T.W. eLife,Volume 9, February 2020, Article number e52504.
Identification of the growth factor-binding sequence in the extracellular matrix protein MAGP-1 (Links to an external site)
Broekelmann, T.J., Bodmer, N.K., *Mecham, R.P. Journal of Biological ChemistryVolume 295, Issue 9, 28 February 2020, Pages 2687-2697.
Effects of high-fat diet on liver injury after small bowel resection (Links to an external site)
Onufer, E.J., Han, Y.-H., Czepielewski, R.S., (…), *Randolph, G.J., Warner, B.W. Journal of Pediatric Surgery, 2020.
Molecular biology of meniscus pathology: Lessons learned from translational studies and mouse models (Links to an external site)
*Rai, M.F., Brophy, R.H., Rosen, V. Journal of Orthopaedic Research2020.
Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility (Links to an external site)
Lee, H.J., Hou, Y., Chen, Y., (…), *Wang, T., *Johnson, S.L. Genome Biology,Volume 21, Issue 1, 27 February 2020, Article number 52
Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2 (Links to an external site)
Hsu, S., Pimenova, A.A., Hayes, K., (…), Goate, A.M., *Karch, C.M. Neurobiology of DiseaseVolume 139, June 2020, Article number 104817.
Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction (Links to an external site)
Ezekian, J.E., Clippinger, S.R., Garcia, J.M., (…), *Greenberg, M.J., Landstrom, A.P. Journal of the American Heart Association, Volume 9, Issue 5, 3 March 2020, Page e015111.
Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee (Links to an external site)
Bailey, K.N., Furman, B.D., Zeitlin, J., (…), *Guilak, F., Olson, S.A. Osteoarthritis and CartilageVolume 28, Issue 5, May 2020, Pages 626-638.
Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology (Links to an external site)
Reichenstein, I., Eitan, C., Diaz-Garcia, S., (…), *Miller, T.M., Hornstein, E. Science Translational Medicine, Volume 11, Issue 523, 18 December 2019, Article number eaav5264
Lymphatic vessels in solid organ transplantation and immunobiology (Links to an external site)
*Wong, B.W. American Journal of Transplantation,2020
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells (Links to an external site)
Hogrebe, N.J., Augsornworawat, P., Maxwell, K.G., Velazco-Cruz, L., *Millman, J.R. Nature Biotechnology, Volume 38, Issue 4, 1 April 2020, Pages 460-470.
Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter (Links to an external site)
Dicks, A., Wu, C.-L., Steward, N., (…), Gersbach, C.A., *Guilak, F. Stem Cell Research and Therapy, Volume 11, Issue 1, 18 February 2020, Article number 66.
CellTagging: combinatorial indexing to simultaneously map lineage and identity at single-cell resolution (Links to an external site)
Kong, W., Biddy, B.A., Kamimoto, K., (…), Butka, E.G., *Morris, S.A. Nature ProtocolsVolume 15, Issue 3, 1 March 2020, Pages 750-772.
Skeletal Muscle Regeneration in Advanced Diabetic Peripheral Neuropathy (Links to an external site)
Bohnert, K.L., Hastings, M.K., Sinacore, D.R., (…), *Gontarz, P., *Meyer, G.A. Foot and Ankle International, Volume 41, Issue 5, 1 May 2020, Pages 536-548
Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival (Links to an external site)
Abreu, D., Asada, R., Revilla, J.M.P., (…), Piston, D.W., *Urano, F. Laboratory InvestigationVolume 100, Issue 6, 1 June 2020, Pages 849-862.
Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing (Links to an external site)
Song, D., He, G., Song, F., (…), *Silva, M.J., Long, F. Bone Research,Volume 8, Issue 1, 1 December 2020, Article number 4
New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity (Review) (Links to an external site)
Rhee, A.J., *Lavine, K.J. Annual Review of Physiology, Volume 82, 2020, Pages 1-20
Pro-elastogenic effects of mesenchymal stem cell derived smooth muscle cells in a 3D collagenous milieu (Links to an external site)
Dahal, S., Swaminathan, G., Carney, S., (…), *Mecham, R., Ramamurthi, A. Acta Biomaterialia, Volume 105, 15 March 2020, Pages 180-190
Induction of WNT16 via peptide-mRNA nanoparticle-based delivery maintains cartilage homeostasis (Links to an external site)
Yan, H., Hu, Y., Akk, A., (…), Wickline, S.A., *Pham, C.T.N. Pharmaceutics, Volume 12, Issue 1, January 2020, Article number 73.
Open search for Rita Levi-Montalcini Postdoctoral Fellows in Regenerative Medicine (Links to an external site)
We are thrilled to announce that we are looking for outstanding candidates for our Rita Levi-Montalcini Postdoctoral Fellows in Regenerative Medicine program. These 2-year fellowships come with salary, travel funds, and research funds. Full details can be found by going to About > Rita Levi-Montalcini Postdoctoral Fellowship. Review of applications will begin August 30.
CRM Co-Director Solnica-Krezel named President-Elect of IZFS (Links to an external site)
CRM Co-Director Lila Solnica-Krezel was recently named President-Elect of the International Zebrafish Society. Congrats, Lila!
Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis (Links to an external site)
Hagan, A.S., *Zhang, B., *Ornitz, D.M. Development,Volume 147: Article number dev181032, 2020.
Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis (Links to an external site)
*Silva, M.J., Holguin, N. FASEB Journal, Volume 34: 1970-1982, 2020.
The role of macrophages in osteoarthritis and cartilage repair (Review) (Links to an external site)
Wu, C.-L., Harasymowicz, N.S., Klimak, M.A., Collins, K.H., *Guilak, F. Osteoarthritis and Cartilage, Volume 28: 544-554, 2020.
Co-opted transposons help perpetuate conserved higher-order chromosomal structures (Links to an external site)
Choudhary, M.N., Friedman, R.Z., Wang, J.T., (…), Zhuo, X., *Wang, T. Genome Biology,Volume 21, Article number 16, 2020.
Advances in the repair of segmental nerve injuries and trends in reconstruction (Links to an external site)
Pan, D., *Mackinnon, S.E., *Wood, M.D. Muscle and NerveVolume 61: 726-739, 2020.