Niu, H., Li, C., Guan, Y., (…), Ma, L., *Guan, J. Acta BiomaterialiaVolume 105, 15 March 2020, Pages 56-67.
Author: abowman
TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy (Links to an external site)
Javaheri, A., Bajpai, G., Picataggi, A., (…), *Lavine, K.J., *Diwan, A. JCI InsightVolume 4, Issue 21, 1 November 2019, Article number e127312.
Isolation of macrophage subsets and stromal cells from human and mouse myocardial specimens (Links to an external site)
Bajpai, G., *Lavine, K.J. Journal of Visualized Experiments,Volume 2019, Issue 154, December 2019, Article number e60015
The age-dependent effect of high-dose X-ray radiation on NFκB signaling, structure, and mechanical behavior of the intervertebral disc (Links to an external site)
Liu, J.W., Piersma, S., *Tang, S.Y. Connective Tissue ResearchVolume 61, Issue 3-4, 3 July 2020, Pages 399-408.
Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development (Links to an external site)
Kelly, N.H., Huynh, N.P.T., *Guilak, F. Matrix Biology, Volume 89, Pages 1-10 2020.
In vitro studies of the synergy between mechanical loading and genetics within human induced pluripotent stem cell derived micro-scale engineered heart tissues (Links to an external site)
*Huebsch, N. MCB Molecular and Cellular Biomechanics, Volume 16, 2019, Pages 107-108.
Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons (Links to an external site)
Lewis, E.M.A., Meganathan, K., Baldridge, D., (…), Constantino, J.N., *Kroll, K.L. Molecular Autism, Volume 10, Issue 1, 30 December 2019, Article number 51.
Rapid determination of internal strains in soft tissues using an experimentally calibrated finite element model derived from magnetic resonance imaging (Links to an external site)
Yoon, D.H.E., Weber, C.I., Easson, G.W.D., Broz, K.S., *Tang, S.Y. Quantitative Imaging in Medicine and Surgery, Volume 10, Issue 1, 2020, Pages 57-65.
Proximal tubule translational profiling during kidney fibrosis reveals proinflammatory and long noncoding RNA expression patterns with sexual dimorphism (Links to an external site)
Wu, H., Lai, C.-F., Chang-Panesso, M., *Humphreys, B.D. Journal of the American Society of Nephrology, Volume 31: 23-38, 2020.
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes (Links to an external site)
Meyer, M., Ben-Yehuda Greenwald, M., Rauschendorfer, T., (…), *Ornitz, D.M., Werner, S. Journal of Cellular and Molecular Medicine,Volume 24: 1774-1785, 2019.
The tetraspanin CD53 regulates early B cell development by promoting IL-7R signaling (Links to an external site)
Greenberg, Z.J., Monlish, D.A., Bartnett, R.L., (…), Bednarski, J.J., *Schuettpelz, L.G. Journal of Immunology, Volume 204: 58-67, 2020.
Targeting Muscles in the Brain to Enhance Cerebral Perfusion (Links to an external site)
Lee, J.-M., *Diwan, A., Zipfel, G.J. JACC: Basic to Translational Science,Volume 4: 959-961, 2019.
Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation (Links to an external site)
Shea, C.A., Rolfe, R.A., *McNeill, H., Murphy, P. Dev Dyn, Volume 249: 523-542, 2020.
Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients (Links to an external site)
Zhang, C.R.C., Nix, D., Gregory, M., (…), Spencer, D.H., *Challen, G.A. Experimental HematologyVolume 80: 36-41.e3, 2019.
Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape
Fearing, B.V., Jing, L., Barcellona, M.N., (…), *Pathak, A., *Setton, L.A. FASEB J, Volume 33: 14022-14035, 2019.
A metastable subproteome underlies inclusion formation in muscle proteinopathies (Links to an external site)
Ciryam, P., Antalek, M., Cid, F., (…), Vendruscolo, M., *Weihl, C.C. Acta Neuropathologica Communications, Volume 7: Article number 197, 2019.
Biology of the caenorhabditis elegans germline stem cell system (Links to an external site)
Albert Hubbard, E.J., *Schedl, T. Genetics, Volume 213: 1145-1188, 2019.
Hyaluronic acid binding to TLR4 promotes proliferation and blocks apoptosis in colon cancer (Links to an external site)
Makkar, S., Riehl, T.E., Chen, B., (…), *Ciorba, M.A., Stenson, W.F. Mol Cancer Ther, Volume 18: 2446-2456, 2019.
SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water (Links to an external site)
Li, H., Russo, A., *DiAntonio, A. J Cell Biology, Volume 218: 4017-4029, 2019.
Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence (Review) (Links to an external site)
Vessoni, A.T., Filippi-Chiela, E.C., Lenz, G., *Batista, L.F.Z. Oncogene, Volume 39: 2055-2068, 2019.
Prioritizing functional goals as we rebuild the kidney (Links to an external site)
*Humphreys, B.D., Knepper, M.A. JASN, Volume 30: 2287-2288, 2019.
The impact of systemic precision medicine and immunotherapy treatments on brain metastases (Review) (Links to an external site)
Han, R.H., Dunn, G.P., Chheda, M.G., *Kim, A.H. Oncotarget, Volume 10: 6739-6753, 2019.
Neutrophils promote VLA-4–dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation (Links to an external site)
Parker Harp, C.R., Archambault, A.S., Cheung, M., (…), *Randolph, G.J., Wu, G.F. PNAS, Volume 116: 24221-24230, 2019.
Imaging in the repair of peripheral nerve injury (Links to an external site)
Luzhansky, I.D., Sudlow, L.C., *Brogan, D.M., *Wood, M.D., *Berezin, M.Y. Nanomedicine, Volume 14: 2659-2677, 2019.
Myocardial glucose and fatty acid metabolism is altered and associated with lower cardiac function in young adults with Barth syndrome (Links to an external site)
*Cade, W.T., Laforest, R., Bohnert, K.L., (…), Gropler, R.J., Peterson, L.R. Journal of Nuclear Cardiology, 2019.
Aaron DiAntonio receives Javits Neuroscience Investigator Award from NINDS
Aaron DiAntonio (Department of Developmental Biology) received a Javits Neuroscience Investigator Award (R37) from the NINDS. Recipients must be nominated by NINDS staff and demonstrate significant, paradigm-shifting contributions to the NINDS mission. The award converts a standard R01 into a 7-year grant. Congratulations, Aaron!
Welcome Matthew Ishahak, Rita Levi-Montalcini Postdoctoral Fellow
On June 1 the CRM welcomed its first Rita Levi-Montalcini Postdoctoral Fellow, Matthew Ishahak. Matthew completed his PhD at the University of Miami, and is joining the lab of CRM member Jeffrey Millman, where he will use his expertise in microfluidics to study stem cell-derived beta cell therapies for diabetes. Welcome, Matthew!
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation (Links to an external site)
Zhi-Feng Miao, Mahliyah Adkins-Threats, Joseph R. Burclaff, …, Zheng He, Zhen-Ning Wang, *Jason C. Mills. Cell Stem Cell, 26:1–16, 2020.
Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development (Links to an external site)
Carissa Dege, Katherine H. Fegan, J. Philip Creamer, …, Todd A. Fehniger, James Palis, *Christopher M. Sturgeon. Dev Cell, 53:1–11, 2020.
Graduate students in CRM labs receive prestigious NSF Graduate Research Fellowship
Three graduate students in CRM labs have been awarded the prestigious NSF Graduate Research Fellowship: Christy Hoffman (Morris Lab), Sophia DeGeorgia (Kaufman Lab), and Daniel Veronese Paniagua (Millman Lab). Laura Fischer (Theunissen Lab) received an honorable mention. Congratulations to all.
Wagenseil to receive Iozzo Award from American Society of Matrix Biology (Links to an external site)
Jessica Wagenseil (Associate Professor, Mechanical Engineering and Materials Science) will receive the Renato Iozzo Award for Outstanding Research in Matrix Biology from the American Society of Matrix Biology at its biennial meeting in November. Congrats, Jessica.
Matt Wood receives first R01 from NINDS
Matthew Wood (Assistant Professor of Surgery) received his first R01 from NINDS, titled “T cell roles in regeneration across nerve graft alternatives.” Congrats, Matt!
Robert Mecham named ISMB 2020 Distinguished Investigator
Bob Mecham (Alumni Endowed Professor of Cell Biology & Physiology) was named the 2020 Distinguished Investigator by the International Society for Matrix Biology. Congrats Bob!
Brown Fat Promotes Muscle Growth During Regeneration (Links to an external site)
Bryniarski, A.R., Meyer, G.A. Journal of Orthopaedic Research, 37(8), pp. 1817-1826, 2019.
DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration (Links to an external site)
Summers, D.W., Frey, E., Walker, L.J., *Milbrandt, J., *DiAntonio, A. Molecular Neurobiology, Volume 57, Issue 2, 1 February 2020, Pages 1146-1158, 2019.
Fat/Dachsous family cadherins in cell and tissue organisation (Links to an external site)
Fulford, A.D., *McNeill, H. Current Opinion in Cell Biology, 62, pp. 96-103, 2020.
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations (Links to an external site)
Dube, U., Del-Aguila, J.L., Li, Z., (…), *Karch, CM., Harari, O., Cruchaga, C. Nature Neuroscience, 22(11), pp. 1903-1912, 2019.
Cis-regulatory basis of sister cell type divergence in the vertebrate retina (Links to an external site)
Murphy, D.P., Hughes, A.E., Lawrence, K.A., Myers, C.A., *Corbo, J.C. eLife, Volume 8, October 2019, Article number e48216, 2019.
β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea (Links to an external site)
Jansson, L., Ebeid, M., Shen, J.W., (…), Huh, S.-H., Cheng, A.G. PNAS, 116(42), pp. 21054-21060, 2019.
DNA Damage Prediction Tool in Dilated Cardiomyopathy: Don’t Go Breaking My Heart (Links to an external site)
Jimenez, J., *Rentschler, S.L. JACC: Basic to Translational Science, 4(6), pp. 681-683, 2019.
Sodium-activated potassium channels moderate excitability in vascular smooth muscle (Links to an external site)
Li, P., Halabi, C.M., Stewart, R., (…), *Mecham, R.P., Salkoff, L. Journal of Physiology, 597(20), pp. 5093-5108, 2019.
Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction (Links to an external site)
Fan, Z., Xu, Z., Niu, H., (…), Ma, J., *Guan, J. Journal of Controlled Release, 311-312, pp. 233-244, 2019.
Platelet-Rich Plasma Released From Polyethylene Glycol Hydrogels Exerts Beneficial Effects on Human Chondrocytes (Links to an external site)
Jain, E., Chinzei, N., Blanco, A., (…), *Rai, M.F., Zustiak, S.P. Journal of orthopaedic research 37(11), pp. 2401-2410, 2019.
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice (Links to an external site)
Yoshida, M., Satoh, A., Lin, J.B., (…), *Apte, R.S., *Imai, S.-I. Cell Metabolism, 30(2), pp. 329-342.e5, 2019.
Musculoskeletal Biology and Regenerative Medicine Meeting Postponed
With the health and safety of the entire community in mind, we have made the difficult decision to postpone the Musculoskeletal Biology and Regenerative Medicine meeting (scheduled for May 28-29, 2020) until May 2021. Once we have confirmed a new date, additional emails will be sent out. Stay safe and healthy.
Welcome to Rowan Karvas, CRM Fellow in the Theunissen Lab
The CRM and the Theunissen Lab welcome Rowan Karvas PhD as a new CRM Fellow in Regenerative Medicine. Rowan received her PhD from the University of Missouri and will work on engineering 3D microenvironments to model early human development. Welcome, Rowan!
Morris awarded a Sloan Research Fellowship (Links to an external site)
Samantha Morris PhD, Assistant Professor of Genetics and of Developmental Biology, was awarded a prestigious Sloan Research Fellowship in Computational and Evolutionary Molecular Biology. Congrats, Sam!
Recent insights into the naïve state of human pluripotency and its applications (Links to an external site)
Dong, C., Fischer, L.A., *Theunissen, T.W. Experimental Cell Research, art. no. 111645, 2019.
Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target (Links to an external site)
Li, Y., Xu, Y., Benitez, B.A., (…), Crawford, B.E., *Sands, M.S. PNAS 116(40), pp. 20097-20103, 2019.
Ultra-low frequency labeling of single cell lineages in Drosophila (Links to an external site)
Snee, M., Lee, W.-C., Beehler-Evans, R., *Micchelli, C.A. Developmental Biology457:9-12, 2020.