Summers, D.W., Frey, E., Walker, L.J., *Milbrandt, J., *DiAntonio, A. Molecular Neurobiology, Volume 57, Issue 2, 1 February 2020, Pages 1146-1158, 2019.
Category: Milbrant
Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program (Links to an external site)
Geisler, S., Doan, R.A., Cheng, G.C., (…), *Milbrandt, J., *DiAntonio, A. JCI Insight, 4(17), art. no. e129920, 2019.
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death (Links to an external site)
Wan, L., Essuman, K., Anderson, R.G., (…), *DiAntonio, A., *Milbrandt, J., Dangl, J.L., Nishimura, M.T. Science, 365(6455), pp. 799-803.
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice (Links to an external site)
*Geisler, S., Huang, S.X., Strickland, A., (…), *DiAntonio, A., *Milbrandt, J. J Exp Med, 216(2), pp. 294-303, 2019.
Gene therapy study has implications for nerve degeneration (Links to an external site)
![](https://regenerativemedicine.wustl.edu/files/2019/01/SARM-DiAntonio-2cxdvbm-350x233.jpg)
Aaron DiAntonio and Jeff Milbrant recently demonstrated the power of blocking the SARM1 pathway for preventing nerve degeneration. Building on previous work, they used adeno-associated virus to deliver a dominant-negative form of the SARM1 protein to mice. When axons in these mice were injured, they were resistant to degeneration. These studies have implications for many […]
New publication from the Milbrandt Lab (Links to an external site)
Avey D, Sankararaman S, Kim AKY, Barve R, Milbrandt J, and Mitra RD. Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia. Cell Rep, 24:3619-3629.e4, 2018.
DiAntonio/Milbrandt Lab Publication featuring Needleman Fellow (Links to an external site)
Karney-Grobe S, Russo A, Frey E, Milbrandt J, and DiAntonio A. HSP90 is a chaperone for DLK and is required for axon injury signaling. PNAS, 2018.