Summers, D.W., Frey, E., Walker, L.J., *Milbrandt, J., *DiAntonio, A. Molecular Neurobiology, Volume 57, Issue 2, 1 February 2020, Pages 1146-1158, 2019.
Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program (Links to an external site)
Geisler, S., Doan, R.A., Cheng, G.C., (…), *Milbrandt, J., *DiAntonio, A. JCI Insight, 4(17), art. no. e129920, 2019.
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death (Links to an external site)
Wan, L., Essuman, K., Anderson, R.G., (…), *DiAntonio, A., *Milbrandt, J., Dangl, J.L., Nishimura, M.T. Science, 365(6455), pp. 799-803.
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice (Links to an external site)
*Geisler, S., Huang, S.X., Strickland, A., (…), *DiAntonio, A., *Milbrandt, J. J Exp Med, 216(2), pp. 294-303, 2019.
Gene therapy study has implications for nerve degeneration (Links to an external site)
Aaron DiAntonio and Jeff Milbrant recently demonstrated the power of blocking the SARM1 pathway for preventing nerve degeneration. Building on previous work, they used adeno-associated virus to deliver a dominant-negative form of the SARM1 protein to mice. When axons in these mice were injured, they were resistant to degeneration. These studies have implications for many […]
New publication from the Milbrandt Lab (Links to an external site)
Avey D, Sankararaman S, Kim AKY, Barve R, Milbrandt J, and Mitra RD. Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia. Cell Rep, 24:3619-3629.e4, 2018.
DiAntonio/Milbrandt Lab Publication featuring Needleman Fellow (Links to an external site)
Karney-Grobe S, Russo A, Frey E, Milbrandt J, and DiAntonio A. HSP90 is a chaperone for DLK and is required for axon injury signaling. PNAS, 2018.