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Adipose tissue is a critical regulator of osteoarthritis (Links to an external site)
Kelsey H. Collins, Kristin L. Lenz, Eleanor N. Pollitt, Daniel Ferguson, Irina Hutson, Luke E. Springer, Arin K. Oestreich, Ruhang Tang, Yun-Rak Choi, *Gretchen A. Meyer, *Steven L. Teitelbaum, *Christine T. N. Pham, Charles A. Harris, and *Farshid Guilak. PNAS USA, 18 (1) e2021096118, 2021.
Computational Stem Cell Biology: Open Questions and Guiding Principles (Links to an external site)
Cahan, P., Cacchiarelli, D., Dunn, S.-J., (…), *Morris, SA, Rackham, OJL, del Sol, A., Wells, C.A. Cell Stem Cell, 28(1), pp. 20-32, 2021.
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration (Links to an external site)
Yo Sasaki, Hiroki Kakita, Shunsuke Kubota, Abdoulaye Sene, Tae Jun Lee, Norimitsu Ban, Zhenyu Dong, Joseph B Lin, Sanford L Boye, *Aaron DiAntonio, Shannon E Boye, *Rajendra S Apte, *Jeffrey Milbrandt. eLife 2020;9:e62027.
Derivation of trophoblast stem cells from naïve human pluripotent stem cells (Links to an external site)
Dong, C., *Beltcheva, M., *Gontarz, P., (…), *Solnica-Krezel, L., *Theunissen, T.W. eLife,Volume 9, February 2020, Article number e52504.
Identification of the growth factor-binding sequence in the extracellular matrix protein MAGP-1 (Links to an external site)
Broekelmann, T.J., Bodmer, N.K., *Mecham, R.P. Journal of Biological ChemistryVolume 295, Issue 9, 28 February 2020, Pages 2687-2697.
Effects of high-fat diet on liver injury after small bowel resection (Links to an external site)
Onufer, E.J., Han, Y.-H., Czepielewski, R.S., (…), *Randolph, G.J., Warner, B.W. Journal of Pediatric Surgery, 2020.
Molecular biology of meniscus pathology: Lessons learned from translational studies and mouse models (Links to an external site)
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Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility (Links to an external site)
Lee, H.J., Hou, Y., Chen, Y., (…), *Wang, T., *Johnson, S.L. Genome Biology,Volume 21, Issue 1, 27 February 2020, Article number 52
Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2 (Links to an external site)
Hsu, S., Pimenova, A.A., Hayes, K., (…), Goate, A.M., *Karch, C.M. Neurobiology of DiseaseVolume 139, June 2020, Article number 104817.
Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction (Links to an external site)
Ezekian, J.E., Clippinger, S.R., Garcia, J.M., (…), *Greenberg, M.J., Landstrom, A.P. Journal of the American Heart Association, Volume 9, Issue 5, 3 March 2020, Page e015111.
Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee (Links to an external site)
Bailey, K.N., Furman, B.D., Zeitlin, J., (…), *Guilak, F., Olson, S.A. Osteoarthritis and CartilageVolume 28, Issue 5, May 2020, Pages 626-638.
Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology (Links to an external site)
Reichenstein, I., Eitan, C., Diaz-Garcia, S., (…), *Miller, T.M., Hornstein, E. Science Translational Medicine, Volume 11, Issue 523, 18 December 2019, Article number eaav5264
Lymphatic vessels in solid organ transplantation and immunobiology (Links to an external site)
*Wong, B.W. American Journal of Transplantation,2020
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells (Links to an external site)
Hogrebe, N.J., Augsornworawat, P., Maxwell, K.G., Velazco-Cruz, L., *Millman, J.R. Nature Biotechnology, Volume 38, Issue 4, 1 April 2020, Pages 460-470.
Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter (Links to an external site)
Dicks, A., Wu, C.-L., Steward, N., (…), Gersbach, C.A., *Guilak, F. Stem Cell Research and Therapy, Volume 11, Issue 1, 18 February 2020, Article number 66.
CellTagging: combinatorial indexing to simultaneously map lineage and identity at single-cell resolution (Links to an external site)
Kong, W., Biddy, B.A., Kamimoto, K., (…), Butka, E.G., *Morris, S.A. Nature ProtocolsVolume 15, Issue 3, 1 March 2020, Pages 750-772.
Skeletal Muscle Regeneration in Advanced Diabetic Peripheral Neuropathy (Links to an external site)
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Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival (Links to an external site)
Abreu, D., Asada, R., Revilla, J.M.P., (…), Piston, D.W., *Urano, F. Laboratory InvestigationVolume 100, Issue 6, 1 June 2020, Pages 849-862.
Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing (Links to an external site)
Song, D., He, G., Song, F., (…), *Silva, M.J., Long, F. Bone Research,Volume 8, Issue 1, 1 December 2020, Article number 4
New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity (Review) (Links to an external site)
Rhee, A.J., *Lavine, K.J. Annual Review of Physiology, Volume 82, 2020, Pages 1-20
Pro-elastogenic effects of mesenchymal stem cell derived smooth muscle cells in a 3D collagenous milieu (Links to an external site)
Dahal, S., Swaminathan, G., Carney, S., (…), *Mecham, R., Ramamurthi, A. Acta Biomaterialia, Volume 105, 15 March 2020, Pages 180-190
Induction of WNT16 via peptide-mRNA nanoparticle-based delivery maintains cartilage homeostasis (Links to an external site)
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Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis (Links to an external site)
Hagan, A.S., *Zhang, B., *Ornitz, D.M. Development,Volume 147: Article number dev181032, 2020.
Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis (Links to an external site)
*Silva, M.J., Holguin, N. FASEB Journal, Volume 34: 1970-1982, 2020.
The role of macrophages in osteoarthritis and cartilage repair (Review) (Links to an external site)
Wu, C.-L., Harasymowicz, N.S., Klimak, M.A., Collins, K.H., *Guilak, F. Osteoarthritis and Cartilage, Volume 28: 544-554, 2020.
Co-opted transposons help perpetuate conserved higher-order chromosomal structures (Links to an external site)
Choudhary, M.N., Friedman, R.Z., Wang, J.T., (…), Zhuo, X., *Wang, T. Genome Biology,Volume 21, Article number 16, 2020.
Advances in the repair of segmental nerve injuries and trends in reconstruction (Links to an external site)
Pan, D., *Mackinnon, S.E., *Wood, M.D. Muscle and NerveVolume 61: 726-739, 2020.
High oxygen preservation hydrogels to augment cell survival under hypoxic condition (Links to an external site)
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TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy (Links to an external site)
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Isolation of macrophage subsets and stromal cells from human and mouse myocardial specimens (Links to an external site)
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The age-dependent effect of high-dose X-ray radiation on NFκB signaling, structure, and mechanical behavior of the intervertebral disc (Links to an external site)
Liu, J.W., Piersma, S., *Tang, S.Y. Connective Tissue ResearchVolume 61, Issue 3-4, 3 July 2020, Pages 399-408.
Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development (Links to an external site)
Kelly, N.H., Huynh, N.P.T., *Guilak, F. Matrix Biology, Volume 89, Pages 1-10 2020.
In vitro studies of the synergy between mechanical loading and genetics within human induced pluripotent stem cell derived micro-scale engineered heart tissues (Links to an external site)
*Huebsch, N. MCB Molecular and Cellular Biomechanics, Volume 16, 2019, Pages 107-108.
Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons (Links to an external site)
Lewis, E.M.A., Meganathan, K., Baldridge, D., (…), Constantino, J.N., *Kroll, K.L. Molecular Autism, Volume 10, Issue 1, 30 December 2019, Article number 51.
Rapid determination of internal strains in soft tissues using an experimentally calibrated finite element model derived from magnetic resonance imaging (Links to an external site)
Yoon, D.H.E., Weber, C.I., Easson, G.W.D., Broz, K.S., *Tang, S.Y. Quantitative Imaging in Medicine and Surgery, Volume 10, Issue 1, 2020, Pages 57-65.
Proximal tubule translational profiling during kidney fibrosis reveals proinflammatory and long noncoding RNA expression patterns with sexual dimorphism (Links to an external site)
Wu, H., Lai, C.-F., Chang-Panesso, M., *Humphreys, B.D. Journal of the American Society of Nephrology, Volume 31: 23-38, 2020.
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes (Links to an external site)
Meyer, M., Ben-Yehuda Greenwald, M., Rauschendorfer, T., (…), *Ornitz, D.M., Werner, S. Journal of Cellular and Molecular Medicine,Volume 24: 1774-1785, 2019.
The tetraspanin CD53 regulates early B cell development by promoting IL-7R signaling (Links to an external site)
Greenberg, Z.J., Monlish, D.A., Bartnett, R.L., (…), Bednarski, J.J., *Schuettpelz, L.G. Journal of Immunology, Volume 204: 58-67, 2020.
Targeting Muscles in the Brain to Enhance Cerebral Perfusion (Links to an external site)
Lee, J.-M., *Diwan, A., Zipfel, G.J. JACC: Basic to Translational Science,Volume 4: 959-961, 2019.
Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation (Links to an external site)
Shea, C.A., Rolfe, R.A., *McNeill, H., Murphy, P. Dev Dyn, Volume 249: 523-542, 2020.
Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients (Links to an external site)
Zhang, C.R.C., Nix, D., Gregory, M., (…), Spencer, D.H., *Challen, G.A. Experimental HematologyVolume 80: 36-41.e3, 2019.
Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape
Fearing, B.V., Jing, L., Barcellona, M.N., (…), *Pathak, A., *Setton, L.A. FASEB J, Volume 33: 14022-14035, 2019.
A metastable subproteome underlies inclusion formation in muscle proteinopathies (Links to an external site)
Ciryam, P., Antalek, M., Cid, F., (…), Vendruscolo, M., *Weihl, C.C. Acta Neuropathologica Communications, Volume 7: Article number 197, 2019.
Biology of the caenorhabditis elegans germline stem cell system (Links to an external site)
Albert Hubbard, E.J., *Schedl, T. Genetics, Volume 213: 1145-1188, 2019.
Hyaluronic acid binding to TLR4 promotes proliferation and blocks apoptosis in colon cancer (Links to an external site)
Makkar, S., Riehl, T.E., Chen, B., (…), *Ciorba, M.A., Stenson, W.F. Mol Cancer Ther, Volume 18: 2446-2456, 2019.
SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water (Links to an external site)
Li, H., Russo, A., *DiAntonio, A. J Cell Biology, Volume 218: 4017-4029, 2019.
Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence (Review) (Links to an external site)
Vessoni, A.T., Filippi-Chiela, E.C., Lenz, G., *Batista, L.F.Z. Oncogene, Volume 39: 2055-2068, 2019.
Prioritizing functional goals as we rebuild the kidney (Links to an external site)
*Humphreys, B.D., Knepper, M.A. JASN, Volume 30: 2287-2288, 2019.
The impact of systemic precision medicine and immunotherapy treatments on brain metastases (Review) (Links to an external site)
Han, R.H., Dunn, G.P., Chheda, M.G., *Kim, A.H. Oncotarget, Volume 10: 6739-6753, 2019.