Prior Seed Grant Awardees

2024

  1. hiPSC-induced retinal organoids modeling CRX-linked retinopathies (PIs: Dr. Shiming Chen and Dr. Chao Zhou)
  2. Personalized kidney organoid modeling to develop novel treatment for uromodulin-associated chronic kidney disease (PIs: Dr. Maggie Chen)
  3. Impact of SLC13A5 LOF mutations on human tissue mineralization (Dr. Naomi Dirckx)

2023

  1. Engineering an In Vitro Model System of Human Implantation and Early Pregnancy Loss (PIs: Oyen and Theunissen) – awarded in partnership with the School of Engineering and the Center for Women’s Health Engineering
  2. A bioengineered composite to promote regeneration following chronic nerve denervation (PIs: Li/Wood)
  3. Toward non-invasive assessment of uterine rupture risk after Cesarean section (PIs: Bersi, Garbow, Neil) – awarded in partnership with the School of Engineering and the Center for Women’s Health Engineering

2022

  1. 3D Printed bioelectric scaffolds for accelerated peripheral nerve regeneration (PIs: Rutz/Wood)
  2. Bioengineered Composite for the Treatment of Peripheral Arterial Disease (PI: Li)
  3. Novel Role of Kif26b in Cartilage Tissue Engineering (PI: Rai) – awarded in partnership with the Musculoskeletal Research Center

2020

  1. Assessment of SARM-1 inhibition and Polethylene Glycol Fusion on the Rapid Return of Function in a Rodent Nerve Injury Model (PIs: Brogan and Milbrandt)
  2. Activation of DNA damage responses as a central element in the development of bone marrow failure (PI: Batista)

2019

  1. Ontogeny of physiologically relevant definitive hematopoietic progenitors (PI: Sturgeon)
  2. A New Discovery Platform to Identify Mechanisms of Muscle Regeneration (PI: Johnson)

2018

  1. The impact of NF1 mutation on excitatory and inhibitory neuron development and function (PIs: Gutmann/Kroll) – awarded in partnership with the IDDRC
  2. Mechanical priming to direct adipose progenitor cells toward an anti-fibrotic phenotype (PIs: Lake/Meyer)
  3. Leveraging macrophage ontogeny to engineer human cardiac tissues to model cardiomyopathy (PIs: Greenberg, Lavine, and Sturgeon)

2016

  1. Improving hematopoietic potential of dyskeratosis congenital cells by modulation of RNA decay pathways (PI: Batista)
  2. Technology development for the study of genetic and environmental causes of diabetes (PI: Millman)
  3. Genome editing in autosomal dominantly inherited muscular dystrophy (PI: Weihl)
  4. Human kidney organoids from iPSCs for modeling kidney fibrosis ($10,000 Postdoctoral award to Zhao Sun, Humphreys Lab)
  5. Cortical interneurons from human embryonic stem cells to study developmental disease modeling ($10,000 postdoctoral award to Kesav Meganathan, Kroll Lab)

2015

  1. Investigation of the Role of Aging in Huntington’s Disease Pathogenesis Using Human Neurons (PI: Yoo)
  2. Direct conversion of human atrial cardiomyocytes into induced-pacemaker cells (PIs: Rentschler, Curiel, and George)
  3. Generation of functional anti tumor NK cells from human pluripotent stem cells (PI: Sturgeon)

2014

  1. Discovery of novel strategies to induce chondrocyte differentiation utilizing iPSC-derived MSCs (PI: McAlinden)
  2. Cortical interneurons from human pluripotent stem cells (PI: Kroll)
  3. Elucidating the genetic relationship between neuropsychiatric disease and cognition using human cerebral organoids (PI: Corbo)