John DiPersio, MD, PhD
Virginia E. & Sam J. Golman Professor of Medicine
Department of Medicine; Chief, Division of Oncology
- Email: jdipersi@nospam.wustl.edu
Core Usage and WUSTL Affiliations:
- Center for Human Immunology and Immunotherapy Programs
- Biologic Therapeutic Core
- Siteman Cancer Center
Selected Grants and Awards:
- Daniel P. Schuster Distinguished Translational Investigator Award
- Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
- American Society of Hematology Mentor Award for Clinical Investigation
Hematopoietic stem cell transplants and CAR-T therapies
Research in the DiPersio Lab is focused on fundamental and translational aspects of leukemia and stem cell biology. These studies include identification of genetic abnormalities in human leukemias, understanding processes involving stem cell and leukemia cell trafficking and clinical and translational programs in both leukemia and stem cell transplantation. The lab focuses on three main areas: 1) mitigating graft versus host disease following hematopoietic stem cell transplantation, 2) developing new T-cell based therapies against leukemia, and 3) identifying novel methods to mobilize hematopoietic stem cells for improved stem cell transplants. These studies have led to successful clinical trials in patients with a variety of hematologic cancers, including Acute Myeloid Leukemia, Multiple Myeloma, and Non-Hodgkin’s Lymphoma.
