W. Todd Cade, PT, PhD

W. Todd Cade, PT, PhD


Program in Physical Therapy, Department of Medicine

Awards and Grants

  • Barth Syndrome Foundation
  • Missouri Spinal Cord Injuries Foundation

Core Usage & WUSTL Affiliations:

  • Diabetes Research Center
  • Nutrition and Obesity Research Center
  • Institute for Clinical & Translational Sciences

Mechanisms of Metabolic Diseases

The Cade laboratory is interested in the mechanisms and treatments (nutritional/exercise/pharmacologic) for skeletal muscle and myocardial substrate (e.g. amino acid, glucose, fatty acid) metabolism, energetic, and functional abnormalities in metabolic diseases such as: Barth syndrome and other pediatric and adult cardiomyopathies, HIV-related metabolic syndrome, diabetes mellitus, and obesity. They are also interested in the effect of the maternal metabolic environment during pregnancy on in utero development and childhood metabolic disease including obesity, diabetes, and HIV. In the case of Barth Syndrome, Dr. Cade is using induced pluripotent stem cells (iPSCs) to investigate the causes of and treatments for the disease.

Selected Publications

  1. Suzuki-Hatano S, Saha M, Rizzo SA, Witko RL, Gosiker BJ, Ramanathan M, Soustek MS, Jones MD, Kang PB, Byrne BJ, Cade WT, Pacak CA. (2018). AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome. Hum Gene Ther. Oct 3, online. 
  2. Cade WT & Cahill AG et al. (2016). Maternal glucose and fatty acid kinetics and infant birth weight in obese women with type 2 diabetes. Diabetes 65:893-901.
  3. Cade WT & Peterson LR et al. (2013). Substrate metabolism during basal and hyperinsulinemic conditions in adolescents and young adults with Barth syndrome. J. Inher. Metabol. Dis. 36:91-101.