Wang, X., Ho, C., Tsatskis, Y., (…), *McNeill, H., Sun, Y., Science Robotics, 4(28), art. no. eaav6180, 2019.
Category: Publications
Immune escape of AML cells after transplantation (Links to an external site)
Marín-Hernández, D., Iñiguez, L.P., Nixon, D.F., (…), *DiPersio, J.F., Ley, T.J., New England Journal of Medicine, 380(13), pp. 1289-1290, 2019.
HDAC5 promotes optic nerve regeneration by activating the mTOR pathway (Links to an external site)
Pita-Thomas, W., Mahar, M., Joshi, A., Gan, D., *Cavalli, V., Experimental Neurology, 317, pp. 271-283, 2019.
MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolismZheng, H., Liu, J., Tycksen, E., Nunley, R., McAlinden, A. (Links to an external site)
Zheng, H., Liu, J., Tycksen, E., Nunley, R., *McAlinden, A., Bone, 123, pp. 92-102, 2019.
IDO1 and kynurenine pathway metabolites activate PI3K-Akt signaling in the neoplastic colon epithelium to promote cancer cell proliferation and inhibit apoptosis (Links to an external site)
Bishnupuri, K.S., Alvarado, D.M., Khouri, A.N., (…), Dieckgraefe, B.K., *Ciorba, M.A., Cancer research, 79(6), pp. 1138-1150, 2019.
Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart (Links to an external site)
Heo, G.S., Kopecky, B., Sultan, D., (…), Liu, Y., *Lavine, K.J., Circulation research, 124(6), pp. 881-890, 2019.
Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis (Links to an external site)
*Rai, M.F., Tycksen, E.D., Cai, L., (…), Wright, R.W., Brophy, R.H., Osteoarthritis and Cartilage, Volume 27, Issue 6, June 2019, Pages 945-955, 2019.
Elastic fibers and biomechanics of the aorta: Insights from mouse studies (Links to an external site)
Yanagisawa, H., Wagenseil, J., Matrix Biology, in press, 2019
A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates (Links to an external site)
Parker, H.J., De Kumar, B., Green, S.A., (…), Bronner, M.E., Krumlauf, R., Nature Communications, 10(1), art. no. 1189, 2019.
New Molecular Scaffolds for Fluorescent Voltage Indicators (Links to an external site)
Boggess, S.C., Gandhi, S.S., Siemons, B.A., (…), Healy, K.E., Miller, E.W., ACS Chemical Biology, 14(3), pp. 390-396, 2019.
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling (Links to an external site)
Zhang, H., Bagherie-Lachidan, M., Badouel, C., (…), *Jain, S., *McNeill, H., Developmental Cell, 48(6), pp. 780-792.e4, 2019.
Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly (Links to an external site)
Lahrouchi, N., George, A., Ratbi, I., (…), Brooks, B.P., Sefiani, A., Nature Communications, 10(1), art. no. 1180, 2019.
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes (Links to an external site)
Lin, J.B., Lin, J.B., Chen, H.C., Chen, T., *Apte, R.S., Scientific Reports, 9(1), art. no. 3799, 2019.
PAI-1 augments mucosal damage in colitis (Links to an external site)
Kaiko, G.E., Chen, F., Lai, C.-W., (…), Liu, T.-C., *Stappenbeck, T.S., Science Translational Medicine, 11(482), art. no. eaat0852, 2019.
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury (Links to an external site)
Shin, J.E., Ha, H., Kim, Y.K., Cho, Y., DiAntonio, A., Neurobiology of Disease, 127, pp. 178-192, 2019.
Lymphatic network remodeling after small bowel resection (Links to an external site)
Onufer, E.J., Czepielewski, R., Seiler, K.M., (…), *Randolph, G.J., Warner, B.W., Journal of Pediatric Surgery, Volume 54, Issue 6, June 2019, Pages 1239-1244, 2019.
Behavioral Compensations and Neuronal Remodeling in a Rodent Model of Chronic Intervertebral Disc Degeneration (Links to an external site)
Leimer, E.M., Gayoso, M.G., Jing, L., (…), Gupta, M.C., Setton, L.A., Scientific Reports, 9(1), art. no. 3759, 2019.
Reduced amount or integrity of arterial elastic fibers alters allometric scaling relationships for aortic diameter and heart weight, but not cardiac function in maturing mice (Links to an external site)
Wagenseil, J.E., Journal of Biomechanical Engineering, 141(4), art. no. 044504-1, 2019.
The Role of Periarticular Soft Tissues in Persistent Motion Loss in a Rat Model of Posttraumatic Elbow Contracture (Links to an external site)
Dunham, C.L., Castile, R.M., Chamberlain, A.M., *Lake, S.P. The Journal of bone and joint surgery. American volume, 101(5), p. e17., 2019.
Visualizing the Heterogeneity of Retinal Microglia (Links to an external site)
Lin, J.B., *Apte, R.S. Immunity, 50:544-46, 2019.
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation (Links to an external site)
Li, W., Feng, G., Gauthier, J.M., (…), *Lavine, K.J., Kreisel, D. JCI, 130, 2019
Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis (Links to an external site)
Kabir, A.U., Lee, T.-J., Pan, H., (…), Miller, M.J., Choi, K. JCI Insight, 3, 2018.
Cardiovascular consequences of KATP overactivity in Cantu syndrome (Links to an external site)
Huang, Y., McClenaghan, C., Harter, T.M., (…), *Remedi, M.S., Nichols, C.G. JCI Insight, 3, 2018.
Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle (Links to an external site)
*Warchol, M.E., Massoodnia, R., Pujol, R., Cox, B.C., Stone, J.S. J Comp Neurol, 2019.
Injectable, thermosensitive, fast gelation, bioeliminable, and oxygen sensitive hydrogels (Links to an external site)
Li, C., Huang, Z., Gao, N., Zheng, J., *Guan, J. Materials Science and Engineering C, 99: 1191-1198, 2019.
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice (Links to an external site)
*Geisler, S., Huang, S.X., Strickland, A., (…), *DiAntonio, A., *Milbrandt, J. J Exp Med, 216(2), pp. 294-303, 2019.
TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension (Links to an external site)
Gilchrist, C.L., Leddy, H.A., Kaye, L., (…), Hoffman, B.D., *Guilak, F. PNAS U S A, 116(6), pp. 1992-1997, 2019.
Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells (Links to an external site)
Velazco-Cruz, L., Song, J., Maxwell, K.G., (…), Hogrebe, N.J., *Millman, J.R. Stem Cell Reports, 12(2), pp. 351-365, 2019.
AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome (Links to an external site)
Suzuki-Hatano, S., Saha, M., Rizzo, S.A., (…), *Cade, W.T., Pacak, C.A. Human Gene Therapy, 30(2), pp. 139-154, 2019.
AAV9-TAZ Gene Replacement Ameliorates Cardiac TMT Proteomic Profiles in a Mouse Model of Barth Syndrome (Links to an external site)
Suzuki-Hatano, S., Saha, M., Soustek, M.S., (…), Cade, W.T., Pacak, C.A. Molecular Therapy – Methods and Clinical Development, 13, pp. 167-179, 2019.
New paper from the Weihl Lab (Links to an external site)
Arhzaouy, K., Papadopoulos, C., Schulze, N., (…), Meyer, H., Weihl, C.C. VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy, 2019.
DiAntonio Lab publication (Links to an external site)
Russo, A., Goel, P., Brace, E.J., (…), Dickman, D., DiAntonio, A. The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat. EMBO Rep, art. e46975, 2019.
New Rai Lab paper (Links to an external site)
Yan, H., Duan, X., Pan, H., (…), Rai, M.F., Pham, C.T.N. Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery. Sci Rep, 9:442, 2019.
New paper from Madison and Mills Labs (Links to an external site)
Osaki, L.H., Bockerstett, K.A., Wong, C.F., (…), DiPaolo, R.J., Mills, J.C. Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia. J Pathol, in press, 2019.
New review article from the Diwan Lab (Links to an external site)
Mani, K., Javaheri, A., Diwan, A. Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor Is the Undercover Boss. Comp Physiol, 8:1639-67, 2018.
New paper from the Millman Lab (Links to an external site)
Millman, J.R., Doggett, T., Thebeau, C., (…), Semenkovich, C.F., Rajagopal, R. Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis, JoVE, 2019.
New review article from Apte Lab
Apte, R.S., Chen, D.S., Ferrara, N. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell, 2019.
New Lavine Lab publication (Links to an external site)
Bajpai, G., Bredemeyer, A., Li, W., (…), Kreisel, D., Lavine, K.J. Tissue Resident CCR2- and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury. Circ Res, 124:263-78, 2019.
Guilak Lab paper (Links to an external site)
Harasymowicz, N.S., Dicks, A., Wu, C.-L., Guilak, F. Physiologic and pathologic effects of dietary free fatty acids on cells of the joint. Annals New York Acad Sci, 2019.
Paper from the Wagenseil Lab (Links to an external site)
Staiculescu, M.C., Cocciolone, A.J., Procknow, J.D., Kim, J., Wagenseil, J.E. Comparative gene array analyses of severe elastic fiber defects in late embryonic and newborn mouse aorta. Physiological Genomics 50:988-1001, 2018.
New paper from Cecilia Pascual-Garrido (Links to an external site)
Pascual-Garrido, C., Aisenbrey, E.A., Rodriguez-Fontan, F., (…), Bryant, S.J., Goodrich, L.R. Photopolymerizable Injectable Cartilage Mimetic Hydrogel for the Treatment of Focal Chondral Lesions: A Proof of Concept Study in a Rabbit Animal Model. Am J Sports Med, 47, 212-21, 2019.
Collaborative paper from Rai, Sandell, Tang, and Silva Labs (Links to an external site)
Rai, M.F., Sandell, L.J., Barrack, T.N., (…), Silva, M.J., Barrack, R.L. A Microarray Study of Articular Cartilage in Relation to Obesity and Severity of Knee Osteoarthritis. Cartilage, 2018.
New Wagenseil Lab paper (Links to an external site)
Cocciolone, A.J., Johnson, E.O., Shao, J.-Y., Wagenseil, J.E. Elastic fiber fragmentation increases transmural hydraulic conductance and solute transport in mouse arteries. J Biomech Engineering, 141, art. no. 021013, 2019.
Review article from the Humphreys Lab (Links to an external site)
Wilson, P.C., Humphreys, B.D. Single-cell genomics and gene editing: implications for nephrology. Nat Rev Nephrol, 2018.
New paper from the Karch Lab (Links to an external site)
Jiang, S., Wen, N., Li, Z., (…), Cruchaga, C., Karch, C.M. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Transl Psych 8, art. no. 265, 2018.
New publication from the Morris Lab (Links to an external site)
Biddy, B.A., Kong, W., Kamimoto, K., (…), Sun, T., Morris, S.A. Single-cell mapping of lineage and identity in direct reprogramming. Nature, 564:219-24, 2018.
New review article from the Karch Lab (Links to an external site)
Tavana, J.P., Rosene, M., Jensen, N.O., (…), Kauwe, J.S.K., Karch, C.M. RAB10: An alzheimer’s disease resilience locus and potential drug target. Clin Interventions Aging, 14:73-9, 2019.
Review article from the Guilak Lab (Links to an external site)
Qu, F., Guilak, F., Mauck, R.L. Cell migration: implications for repair and regeneration in joint disease. Nat Rev Rheumatol, 2019.
Review article from the Ornitz Lab (Links to an external site)
Ornitz, D.M., Marie, P.J. Fibroblast growth factors in skeletal development. Curr Opin Dev Biol, 2019.
New Cavalli Lab publication (Links to an external site)
Oh, Y.M., Mahar, M., Ewan, E.E., (…), Zhao, G., Cavalli, V. Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. PNAS, 115:E12417-26, 2018.