Jennifer Alexander-Brett, MD, PhD

Jennifer Alexander-Brett, MD, PhD

Assistant Professor, Department of Medicine, Division of Pulmonary & Critical Care Medicine

The Alexander-Brett Lab integrates mucosal immunology, epithelial stem cell biology and protein biochemistry to investigate the role of stromal-immune intercellular crosstalk via extracellular vesicles in driving chronic lung disease pathogenesis.

Alexander-Brett Lab website »

Valeria Cavalli, PhD

Valeria Cavalli, PhD

Associate Professor

Department of Neuroscience

The Cavalli lab studies the molecular mechanisms of PNS injury signaling and axon regrowth, and how this can inform CNS regeneration.

 

Cavalli Lab website »

Grant Challen, PhD

Grant Challen, PhD

Associate Professor, Division of Oncology, Department of Medicine

The Challen lab focuses on how epigenetic marks regulate HSC self-renewal and differentiation, and how these are altered in lymphoma and leukemia.

 

Challen Lab website »

David Chen, MD, PhD

David Chen, MD, PhD

Assistant Professor, Department of Medicine, Division of Dermatology

The Chen Lab is interested in defining the genetic and epigenetic drivers of premalignant states in skin cancer.

Chen Lab Website »

Joseph Corbo, MD, PhD

Joseph Corbo, MD, PhD

Professor

Department of Pathology and Immunology

The Corbo lab studies the transcriptional regulatory networks that underlie the development, evolution, and diseases of photoreceptors.

 

Corbo Lab website »

Xiaoxia Cui, PhD

Xiaoxia Cui, PhD

Associate Professor and Director, Genome Engineering & Stem Cell Center

Dr. Cui directs the Genome Engineering & Stem Cell Center at Washington University. The GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab.

Genome Engineering & Stem Cell Center website »

Yifan Dai, PhD

Yifan Dai, PhD

Assistant Professor, Biomedical Engineering

The Dai Lab focuses on exploring the physical chemistry of biology to understand how chemical functions are encoded in biological soft matter. Their goal is to use fundamental capabilities of synthetic biology to design smart medicine capable of sensing and responding to cellular states for the improvement of human well-being.

Dai Lab website »

Sabine M Dietmann, PhD

Sabine M Dietmann, PhD

Assistant Professor of Developmental Biology and Medicine, School of Medicine

The Dietmann Lab specializes in the development of integrative multi-omics and machine learning approaches to the complex data sets generated by single-cell sequencing technologies in developmental biology and medicine. Her research has focused on the epigenetic landscape of embryonic stem cells and in vitro systems of human development. Of particular recent interest are studies of human organoids for applications in medicine and comparing developmental trajectories with other species and cell-cell communication. 

Dietmann Lab website »

Farshid Guilak, PhD

Farshid Guilak, PhD

Co-Director, Center of Regenerative Medicine; Mildred B. Simon Professor of Orthopedic Surgery; Director of Research, Shriner's Hospitals - St. Louis

The Guilak Lab is pursuing a multidisciplinary approach to investigate the etiology and pathogenesis of osteoarthritis, as a basis for the development of new pharmacologic and stem cell therapies.

 

Guilak Lab website »

Nathaniel Huebsch, PhD

Nathaniel Huebsch, PhD

Assistant Professor, Biomedical Engineering

Professor Huebsch's research focus is in basic and translational stem cell mechanobiology, with specific focus on hydrogels to control cell-mediated tissue repair, and 3-D models heart-on-a-chip models derived from human induced pluripotent stem cells.

 

Faculty profile »

Sanjay Jain, MD, PhD

Sanjay Jain, MD, PhD

Associate Professor, Division of Nephrology, Department of Medicine

The Jain lab studies the molecular and cellular mechanisms that regulate maintenance, differentiation and function of kidney progenitors in normal development and disease states.

 

Jain Lab website »

Sheng Chih (Peter) Jin, PhD

Sheng Chih (Peter) Jin, PhD

Assistant Professor, Department of Genetics

Research in the Jin lab is devoted to identifying the genes and elucidating the molecular, cellular, and developmental mechanisms that drive the development of specific neurodevelopmental disorders, including congenital hydrocephalus, cerebral palsy, and Moyamoya disease.

 

Jin Lab »

Charles Kaufman, MD, PhD

Charles Kaufman, MD, PhD

Assistant Professor, Division of Oncology, Department of Medicine

The goal of the Kaufman lab is to understand how cells change their gene expression programs during normal development and cancer formation.

 

Kaufman Lab website »

Albert Kim, MD, PhD

Albert Kim, MD, PhD

Professor, Neurosurgery

The Kim Lab studies the cell-intrinsic molecular mechanisms governing brain cancer stem cell function, normal nervous system development, and the development of clinical surgical protocols to deliver cell-based and drug therapies for a variety of nervous system disorders.

 

Kim Lab website »

Kristen Kroll, PhD

Kristen Kroll, PhD

Professor, Developmental Biology

The Kroll lab studies the epigenetic and transcriptional regulators that control fate decisions from embryonic stem cells into the neural lineage.

 

Kroll Lab website »

Michael Meers, PhD

Michael Meers, PhD

Assistant Professor, Department of Genetics

The Meers Lab studies how transcription factors interact with and overcome barriers presented by chromatin landscapes to specify developmental and cellular reprogramming outcomes. To do so, we develop cutting-edge epigenomics techniques to map transcription factor binding and chromatin structure in the same context at high resolution.
Sumegha Mitra, MS, PhD

Sumegha Mitra, MS, PhD

Associate Professor of Obstetrics and Gynecology

Dr. Mitra is focused on chemotherapy stress-induced mechanisms that provide resistance to endoplasmic reticulum stress and promote cell survival. She is also interested in regulating protein homeostasis to re-sensitize chemoresistant ovarian cancer to platinum drugs.

Mitra Lab website »

Samantha Morris, PhD

Samantha Morris, PhD

Associate Professor of Genetics and of Developmental Biology

The Morris lab studies the gene regulatory networks that define cell fate. This information is applied to engineer cell identity, and to better understand cell fate decisions in development and disease.

 

Morris Lab website »

Regis O'Keefe, MD, PhD

Regis O'Keefe, MD, PhD

Fred C. Reynolds Professor and Head of Orthopedic Surgery

The O’Keefe lab studies skeletal development and repair, cancer, and inflammatory diseases of bone.

 

O'Keefe Lab website »

Arin Oestreich

Arin Oestreich

Assistant Professor of Orthopaedic Surgery

Dr. Oestreich's research focuses on how maternal obesity influences pregnancy health, fetal skeletal development, and the long term metabolic and musculoskeletal health of the adult offspring.

Faculty profile website »

B. Duygu Ozpolat, PhD

B. Duygu Ozpolat, PhD

Assistant Professor, Department of Biology

If humans lose their reproductive cells (i.e eggs and sperm) they become infertile, in contrast, some animals regenerate their reproductive cells and reproductive organs. The Ozpolat lab's goal is to uncover the mechanisms of reproductive cell and tissue regeneration by identifying the cell types and genes involved in this process, which will inform regenerative medicine approaches.

Ozpolat lab website »

Michael Rauchman, MDCM

Michael Rauchman, MDCM

Professor, Division of Nephrology, Department of Medicine

Dr. Rauchman’s research focuses on understanding the molecular and genetic basis of mammalian kidney development, how disruption of specific pathways leads to abnormal development of this organ, the consequences of injury to adult kidney and the relationship between genetic mutations in humans and the development of future cardiovascular and renal disorders in humans.

 

Faculty profile »

Stacey Rentschler, MD, PhD

Stacey Rentschler, MD, PhD

Associate Professor, Division of Cardiology, Department of Medicine

The Rentschler lab studies the molecular mechanisms of conduction cell specification and conductive disorders in heart biology.

 

Faculty profile »

Mark Sands, PhD

Mark Sands, PhD

Professor, Division of Oncology, Department of Medicine

The Sands lab studies the underlying pathophysiology of lysosomal storage diseases and develops therapies to treat them.

 

Faculty profile »

Jie Shen, PhD

Jie Shen, PhD

Assistant Professor, Orthopedic Surgery

The Shen laboratory recently works on epigenetics of degenerative and regenerative processes in the muscuoskeletal system, e.g. osteoarthritis and bony fracture. They employ unbiased approaches to study the genomic and epigenomic alterations in skeletal diseases.

Lilianna Solnica-Krezel, PhD

Lilianna Solnica-Krezel, PhD

Co-Director, Center of Regenerative Medicine; Alan A. and Edith L. Wolff Distinguished Professor and Head of Developmental Biology

The Solnica-Krezel lab studies the cellular and molecular genetic mechanisms underlying vertebrate gastrulation in zebrafish and human embryonic stem cells.

 

Solnica-Krezel Lab website »

Stephen Stone, MD

Stephen Stone, MD

Instructor, Department of Pediatrics

Dr. Stone studies the role of Fibroblast Growth Factors in Severe Insulin Resistance Syndromes. His research uses both murine and stem cell based models to better understand these rare and debilitating conditions, with the ultimate goal of providing new therapies for these patients.

Thorold Theunissen, PhD

Thorold Theunissen, PhD

Assistant Professor, Developmental Biology; co-Director Human Cells, Tissues, and Organoids Core

The Theunissen lab investigates the molecular mechanisms regulating distinct pluripotent stem cell states and their applications in regenerative medicine.

 

Theunissen Lab website »

Ting Wang, PhD

Ting Wang, PhD

Sanford C. and Karen P. Loewentheil Distinguished Professor, Genetics

The Wang lab focuses on understanding genetic and epigenetic factors that determine cell fate, including cell fate decision in normal development and differentiation, abnormal cell fate choice in cancer, and how specific cell types evolve.

 

Wang Lab website »

Kel Vin Woo, MD, PhD

Kel Vin Woo, MD, PhD

Instructor of Pediatrics

The Woo lab studies vascular remodeling from the perspective of endothelial and smooth muscle cell reprogramming as induced by hypoxia.

Faculty profile website »

Hiroko Yano, PhD

Hiroko Yano, PhD

Associate Professor, Neurosurgery

The Yano Lab is interested in mechanisms leading to neurodegenerative diseases and brain tumors and the development of disease therapies.

 

Yano Lab website »

Andrew Yoo, PhD

Andrew Yoo, PhD

Associate Professor, Developmental Biology

The Yoo lab studies how microRNAs control development, direct reprogramming, and aging in neurons.

 

Yoo Lab website »